{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T18:32:02Z","timestamp":1762194722715,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,5,3]],"date-time":"2011-05-03T00:00:00Z","timestamp":1304380800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>Recent reports of bisphosphonate\u2010related osteonecrosis of the jaw (BRONJ) have increased awareness of oral health in patients receiving osteoporosis therapy. This study describes the demographic, oral health, and clinical characteristics of a contemporary population of women aged 50 and older undergoing oral bisphosphonate treatment who returned a mailed questionnaire pertaining to dental symptoms. The study, as previously reported, was conducted within Kaiser Permanente Northern California, a large, integrated healthcare delivery system. The cohort included 7,909 women with bisphosphonate exposure of at least 1 year, with a subset of 923 women reporting dental symptoms who underwent clinical examination. Overall, the average age was 71\u00b19; 70% were white, and 74% had at least some college education. Nearly two\u2010thirds had received oral bisphosphonate therapy for 3 or more years. Most reported daily tooth brushing, 85% had had a dental examination in the past year, 22% reported denture use, and 6% reported moderate to severe periodontal disease. Oral healthcare patterns varied according to age and race and ethnicity. Five hundred seven (6.4%) women reported a tooth extraction in the prior year, of whom two developed BRONJ (0.4%). Tori or exostoses were found in 28% of examined participants with dental symptoms; these were predominantly in the lingual mandible and palate, with palatal BRONJ occurring in 1.6% of symptomatic participants with palatal tori. In summary, among older women with bisphosphonate exposure, oral health varied according to patient characteristics, and BRONJ occurred more frequently after tooth extraction or on palatal tori. These data support efforts to optimize oral health and to identify risk factors for BRONJ in older individuals receiving bisphosphonate drugs.<\/jats:p>","DOI":"10.1111\/j.1532-5415.2011.03371.x","type":"journal-article","created":{"date-parts":[[2011,5,3]],"date-time":"2011-05-03T18:00:19Z","timestamp":1304445619000},"page":"916-922","source":"Crossref","is-referenced-by-count":12,"title":["Oral Health Considerations in Older Women Receiving Oral Bisphosphonate Therapy"],"prefix":"10.1111","volume":"59","author":[{"given":"Joan C.","family":"Lo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felice","family":"O'Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingrong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad K.","family":"Hararah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel R.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Silver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Ansfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan S.","family":"Go","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,5,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.03.050"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2008.12.004"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.01.009"},{"key":"e_1_2_6_5_2","first-page":"527","article-title":"Osteonecrosis of the jaws associated with the use of bisphosphonates","volume":"62","author":"Ruggiero SL","year":"2004","journal-title":"A review of 63 cases"},{"key":"e_1_2_6_6_2","first-page":"753","article-title":"Narrative [corrected] review","volume":"144","author":"Woo SB","year":"2006","journal-title":"Bisphosphonates and osteonecrosis of the jaws"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.10.061"},{"key":"e_1_2_6_8_2","first-page":"2397","article-title":"Oral bisphosphonate\u2010induced osteonecrosis","volume":"65","author":"Marx RE","year":"2007","journal-title":"Risk factors, prediction of risk using serum CTX testing, prevention, and treatment"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2008.00078.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.05.041"},{"key":"e_1_2_6_11_2","first-page":"70","article-title":"Efficacy of bisphosphonates for the control of alveolar bone loss in periodontitis","volume":"9","author":"Jeffcoat MK","year":"2007","journal-title":"J Int Acad Periodontol"},{"key":"e_1_2_6_12_2","first-page":"576","article-title":"Response of diffuse sclerosing osteomyelitis of the mandible to alendronate","volume":"34","author":"Hino S","year":"2005","journal-title":"Follow-up study by 99mTc scintigraphy"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.11.003"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.09.055"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.1.11"},{"key":"e_1_2_6_16_2","first-page":"1154","article-title":"Dental visits among older U.S. adults, 1999","volume":"135","author":"Macek MD","year":"2004","journal-title":"The roles of dentition status and cost"},{"key":"e_1_2_6_17_2","first-page":"1","article-title":"Trends in oral health status","volume":"11","author":"Dye BA","year":"2007","journal-title":"United States, 1988\u20131994 and 1999\u20132004"},{"key":"e_1_2_6_18_2","first-page":"1226","article-title":"Public health and aging","volume":"52","year":"2003","journal-title":"Retention of natural teeth among older adults\u2013United States, 2002"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh245"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.gme.0000184421.50696.34"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2007.00406.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.1.13"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-009-0090-6"},{"key":"e_1_2_6_24_2","first-page":"93","article-title":"Dental extractions and bisphosphonates","volume":"206","author":"Malden N","year":"2009","journal-title":"The assessment, consent and management, a proposed algorithm"},{"key":"e_1_2_6_25_2","unstructured":"Clinician's Guide to Prevention and Treatment of Osteoporosis: National Osteoporosis Foundation; 2008."},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.12.003"},{"key":"e_1_2_6_27_2","first-page":"20","article-title":"Bisphosphonate use and health history questionnaire","volume":"74","author":"Dao V","year":"2008","journal-title":"N Y State Dent J"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2010.0229"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(86)90010-1"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(53)90225-4"},{"key":"e_1_2_6_31_2","first-page":"2081","article-title":"Torus palatinus","volume":"88","author":"Belsky JL","year":"2003","journal-title":"A new anatomical correlation with bone density in postmenopausal women"},{"key":"e_1_2_6_32_2","first-page":"60","article-title":"Concurrence of torus mandibularis and torus palatinus","volume":"102","author":"Eggen S","year":"1994","journal-title":"Scand J Dent Res"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1532-5415.2011.03371.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1532-5415.2011.03371.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T18:15:08Z","timestamp":1762193708000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/j.1532-5415.2011.03371.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1111\/j.1532-5415.2011.03371.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1532-5415.2011.03371.x","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"type":"print","value":"0002-8614"},{"type":"electronic","value":"1532-5415"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}