{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T05:10:22Z","timestamp":1792559422119,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,6,7]],"date-time":"2011-06-07T00:00:00Z","timestamp":1307404800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>\n                    <jats:bold>OBJECTIVES:<\/jats:bold>\n                    To evaluate studies that have assessed the effect of dehydroepiandrosterone (DHEA) supplementation on body composition and physical performance in older adults.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>DESIGN:<\/jats:bold>\n                    A systematic review of the medical literature identified from searches of databases, reference lists, and recent conference proceedings with qualitative assessment of the desired end points.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>SETTING:<\/jats:bold>\n                    Not applicable.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>PARTICIPANTS:<\/jats:bold>\n                    Adults aged 50 and older.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>INTERVENTIONS:<\/jats:bold>\n                    Oral DHEA supplement with or without concomitant exercise.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>MEASUREMENTS:<\/jats:bold>\n                    Muscle strength, physical function, and physical performance.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    Of the 155 eligible studies, eight (n=661 participants) met inclusion criteria. The studies differed in their included populations, duration of follow\u2010up, and interventions (e.g., exercise). Seven studies examined measures of muscle strength. One study showed improvement in handgrip strength, one showed improvement in chest press, two showed improvement in leg press, and one showed improvement in knee extension and flexion. Nevertheless, similar numbers of studies had negative results for each of these endpoints. Five studies examined measures of physical function and performance. Only one study showed improvement in a composite score measuring physical performance; the rest reported no differences between DHEA and control for any end point.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION:<\/jats:bold>\n                    Overall, the benefit of DHEA on muscle strength and physical function in older adults remains inconclusive. Some measures of muscle strength may improve, although consensus was not reached. DHEA does not appear to routinely benefit measures of physical function or performance. Further large clinical trials are necessary to better identify the clinical role of DHEA supplementation in this population.\n                  <\/jats:p>","DOI":"10.1111\/j.1532-5415.2011.03410.x","type":"journal-article","created":{"date-parts":[[2011,6,7]],"date-time":"2011-06-07T12:23:45Z","timestamp":1307449425000},"page":"997-1002","source":"Crossref","is-referenced-by-count":59,"title":["Effect of Dehydroepiandrosterone on Muscle Strength and Physical Function in Older Adults: A Systematic Review"],"prefix":"10.1111","volume":"59","author":[{"given":"William L.","family":"Baker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shobha","family":"Karan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,7]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.75.4.1002"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.5.1529"},{"key":"e_1_2_7_4_2","first-page":"1833","article-title":"Endogenous sex steroids and bone mineral density in older women and men","volume":"12","author":"Greendale GA","year":"1997","journal-title":"The Rancho Bernardo Study"},{"key":"e_1_2_7_5_2","first-page":"473","article-title":"Longitudinal changes in body composition in older men and women","volume":"76","author":"Hughes VA","year":"2002","journal-title":"Role of body weight change and physical activity"},{"issue":"5","key":"e_1_2_7_6_2","first-page":"990S","article-title":"Sarcopenia","volume":"127","author":"Rosenberg IH.","year":"1997","journal-title":"Origins and clinical relevance"},{"key":"e_1_2_7_7_2","first-page":"1059","article-title":"The loss of skeletal muscle strength, mass, and quality in older adults","volume":"61","author":"Goodpaster BH","year":"2006","journal-title":"The Health, Aging and Body Composition Study"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28047"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/57.12.M772"},{"key":"e_1_2_7_10_2","first-page":"1129","article-title":"High, usual and impaired functioning in community\u2010dwelling older men and women","volume":"46","author":"Berkman LF","year":"1993","journal-title":"Findings from the MacArthur Foundation Research Network on Successful Aging"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-199800640-00002"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1998.tb01036.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03324545"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afp015"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.03019.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1027"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2433"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054629"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00100.2006"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.6.720"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.10.7974"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00507.x"},{"key":"e_1_2_7_23_2","first-page":"391","article-title":"Supplementation with DHEA","volume":"14","author":"Dayal M","year":"2005","journal-title":"Effect on muscle size, strength, quality of life, and lipids"},{"key":"e_1_2_7_24_2","first-page":"2986","article-title":"Effects of dehydroepiandrosterone replacement therapy on bone mineral density in older adults","volume":"91","author":"Jankowski CM","year":"2006","journal-title":"A randomized, controlled trial"},{"key":"e_1_2_7_25_2","first-page":"699","article-title":"Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults","volume":"19","author":"von Muhlen D","year":"2008","journal-title":"The DAWN trial"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq043"},{"key":"e_1_2_7_27_2","first-page":"264","article-title":"Preferred reporting items for systematic reviews and meta\u2010analyses","volume":"151","author":"Moher D","year":"2009","journal-title":"The PRISMA statement"},{"key":"e_1_2_7_28_2","unstructured":"Agency for Healthcare Research and Quality. Methods Guide for Comparative Effectiveness Reviews Version 1.0 Rockville MD Agency for Healthcare Research and Quality; October 2007 [on\u2010line]. Available athttp:\/\/effectivehealthcare.ahrq.gov\/repFiles\/2007_10DraftMethodsGuide.pdfAccessed August 25 2010."},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(91)90116-A"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00678.2007"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2009.12.002"},{"key":"e_1_2_7_32_2","first-page":"1820","article-title":"Point: Counterpoint","volume":"108","author":"Stewart CE","year":"2010","journal-title":"IGF is\/is not the major physiological regulator of muscle mass. Point: IGF is the major physiological regulator of muscle mass"},{"key":"e_1_2_7_33_2","first-page":"659","article-title":"Cellular and molecular signatures of muscle regeneration","volume":"122","author":"Wagers AJ","year":"2005","journal-title":"Current concepts and controversies in adult myogenesis"},{"key":"e_1_2_7_34_2","first-page":"3600","article-title":"No evidence for hepatic conversion of dehydroepiandrosterone (DHEA) sulfate to DHEA","volume":"90","author":"Hammer F","year":"2005","journal-title":"In vivo and in vitro studies"},{"key":"e_1_2_7_35_2","first-page":"127","article-title":"Dehydroepiandrosterone to enhance physical performance","volume":"39","author":"Hahner S","year":"2010","journal-title":"Myth and reality"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.10.032"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03440100097014"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1532-5415.2011.03410.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1532-5415.2011.03410.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:41:26Z","timestamp":1762177286000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/j.1532-5415.2011.03410.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1111\/j.1532-5415.2011.03410.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1532-5415.2011.03410.x","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}