{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:22:08Z","timestamp":1791033728005,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T00:00:00Z","timestamp":1309392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>\n                    <jats:bold>OBJECTIVES:<\/jats:bold>\n                    To study white matter lesions (WMLs) and 5\u2010year cognitive decline in elderly Japanese\u2010American men.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>DESIGN:<\/jats:bold>\n                    Longitudinal cohort study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>SETTING:<\/jats:bold>\n                    Population\u2010based study in Honolulu, Hawaii.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>PARTICIPANTS:<\/jats:bold>\n                    Japanese\u2010American men aged 74 to 95 from the Honolulu\u2010Asia Aging Study (HAAS) who were free of prevalent dementia, underwent a protocol brain MRI scan at the fifth HAAS examination (1994\u20131996), and returned for cognitive testing 5 years later (N=267).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>MEASUREMENTS:<\/jats:bold>\n                    WMLs were dichotomized as present (grade 3\u20139, 38.2%) or absent (grade 1\u20132, 61.8%). Cognitive function was measured using the Cognitive Abilities Screening Instrument (CASI), and 5\u2010year cognitive decline was defined as a drop in CASI score of 12 points or more (1 standard deviation).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    Men with WMLs on MRI at baseline were significantly more likely to experience cognitive decline at 5 years than those without (22.4% vs 34.4%,\n                    <jats:italic>P<\/jats:italic>\n                    =.03). Using multiple logistic regression, adjusting for age, education, apolipoprotein (Apo)E4 allele, large or small infarcts on MRI, baseline CASI score, and hypertension, those with WMLs were significantly more likely to develop 5\u2010year cognitive decline (odds ratio=2.00, 95% confidence interval=1.10\u20133.65,\n                    <jats:italic>P<\/jats:italic>\n                    =.02). This association was stronger in men who were cognitively intact and free of the ApoE4 genotype and clinical stroke at baseline.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION:<\/jats:bold>\n                    Presence of WMLs on MRI was significantly associated with higher odds of 5\u2010year cognitive decline in older Japanese\u2010American men. Presence of WMLs may help identify people at risk for developing dementia, who may benefit from early intervention.\n                  <\/jats:p>","DOI":"10.1111\/j.1532-5415.2011.03490.x","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T15:29:37Z","timestamp":1309447777000},"page":"1484-1489","source":"Crossref","is-referenced-by-count":46,"title":["White Matter Lesions on Brain Magnetic Resonance Imaging Scan and 5\u2010Year Cognitive Decline: The Honolulu\u2010Asia Aging Study"],"prefix":"10.1111","volume":"59","author":[{"given":"Michiko","family":"Inaba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lon","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Petrovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore","family":"Launer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Abbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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