{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:50:36Z","timestamp":1761580236792},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,9,13]],"date-time":"2004-09-13T00:00:00Z","timestamp":1095033600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p><jats:bold>Objective\u2014<\/jats:bold>To evaluate postoperative complications, limb function, and tumor control after intercalary resection and reconstruction for preservation of limb and joint function in dogs with high\u2010grade malignant tumors of diaphyseal bone.<\/jats:p><jats:p><jats:bold>Study Design\u2014<\/jats:bold>Retrospective study.<\/jats:p><jats:p><jats:bold>Animals\u2014<\/jats:bold>Seventeen client\u2010owned dogs.<\/jats:p><jats:p><jats:bold>Methods\u2014<\/jats:bold>The bone tumor database and medical records were reviewed (1986\u20132002) for dogs with diaphyseal tumors treated with intercalary resection and reconstruction with either an allograft or irradiated autograft. Clinical presentation, diagnostic findings, surgical management, and outcome were determined from medical records and telephone interviews with veterinarians and owners. Statistical analyses included \u03c7<jats:sup>2<\/jats:sup>to test associations between intra\u2010 and postoperative variables with complications, and Kaplan\u2013Meier survival analysis for disease\u2010free interval, metastasis\u2010free interval (MFI), and median survival time.<\/jats:p><jats:p><jats:bold>Results\u2014<\/jats:bold>Intercalary limb\u2010sparing surgery was performed in 17 dogs with diaphyseal tumors: osteosarcoma (OSA) (15), histiocytic sarcoma (1), and solitary metastasis from a pulmonary adenocarcinoma (1). One dog was excluded from further analysis when the spared limb was amputated 4 days postoperatively because of incomplete tumor resection. In 16 dogs, limb function was good to excellent. Complications occurred in 5 dogs (31.3%) and included superficial infection in 2 dogs (12.5%) and implant failure in 4 dogs (25%). All implant failures occurred in the ulna and there was a significant association between implant failure and non\u2010cemented allografts (<jats:italic>P<\/jats:italic>=.042). Non\u2010union of 1 or both osteotomies was diagnosed in 10 dogs (83.3%) and, despite lack of clinical signs in all cases, was significantly associated with the use of intracavitary locally released cisplatin (<jats:italic>P<\/jats:italic>=.046) and cemented intercalary grafts (<jats:italic>P<\/jats:italic>=.046). Local tumor recurrence was diagnosed in 1 dog (6.3%) and metastatic disease in 12 dogs (75.0%), including 10 dogs with OSA. The median MFI was 137 days. The local disease\u2010free and overall limb\u2010salvage rate was 94% and 100%, respectively. Overall median survival time was 393 days and the median survival time for dogs with OSA was 449 days.<\/jats:p><jats:p><jats:bold>Conclusion\u2014<\/jats:bold>Intercalary limb\u2010sparing surgery results in better postoperative limb function with fewer and less severe complications than historical reports of dogs treated with non\u2010intercalary limb\u2010sparing surgery.<\/jats:p><jats:p><jats:bold>Clinical Relevance\u2014<\/jats:bold>In dogs with diaphyseal tumors, intercalary limb\u2010sparing surgery preserves normal joint function and results in good to excellent limb use with few complications and good local tumor control.<\/jats:p>","DOI":"10.1111\/j.1532-950x.2004.04069.x","type":"journal-article","created":{"date-parts":[[2004,9,13]],"date-time":"2004-09-13T09:25:29Z","timestamp":1095067529000},"page":"457-467","source":"Crossref","is-referenced-by-count":15,"title":["Intercalary Bone Grafts for Joint and Limb Preservation in 17 Dogs with High\u2010Grade Malignant Tumors of 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