{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:18:26Z","timestamp":1782296306309,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,8,3]],"date-time":"2006-08-03T00:00:00Z","timestamp":1154563200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold>Objective\u2014<\/jats:bold>To investigate the effect of cyclosporine (2 or 5\u2003mg\/kg every 24 hours) on perianal fistulae (PAF) lesions.<\/jats:p><jats:p><jats:bold>Study Design\u2014<\/jats:bold>Blinded randomized, prospective trial.<\/jats:p><jats:p><jats:bold>Animals\u2014<\/jats:bold>Dogs (n=20) with perianal fistulae.<\/jats:p><jats:p><jats:bold>Methods\u2014<\/jats:bold>Dogs were randomly assigned to administration of either 2\u2003mg\/kg (n=10) or 5\u2003mg\/kg (n=10) of cyclosporine orally every 24 hours for 8 weeks. Lesion surface area was measured, lesion severity was graded using a visual analog scale, and the presence and severity of clinical signs recorded every 2 weeks.<\/jats:p><jats:p><jats:bold>Results\u2014<\/jats:bold>Lesion variables were significantly reduced in both groups after 8 weeks and owners also reported a reduction in clinical sign severity. The 5\u2003mg\/kg dose rate significantly accelerated lesion resolution compared with 2\u2003mg\/kg. In the 2\u2003mg\/kg group, 20% of dogs had complete resolution of clinical signs and 10% had resolution of lesions. In the 5\u2003mg\/kg group, 40% of dogs had complete resolution of clinical signs and 60% had resolution of lesions.<\/jats:p><jats:p><jats:bold>Conclusions\u2014<\/jats:bold>A dose rate of 5\u2003mg\/kg every 24 hours was more effective at reducing the surface area and severity of PAF lesions than 2\u2003mg\/kg every 24 hours but less effective at resolving PAF lesions than previous studies using dose rates \u22655\u2003mg\/kg every 12 hours.<\/jats:p><jats:p><jats:bold>Clinical Relevance\u2014<\/jats:bold>Cyclosporine at 5\u2003mg\/kg every 24 hours may be useful for the palliation of PAF lesions.<\/jats:p>","DOI":"10.1111\/j.1532-950x.2006.00187.x","type":"journal-article","created":{"date-parts":[[2006,8,3]],"date-time":"2006-08-03T09:38:29Z","timestamp":1154597909000},"page":"543-549","source":"Crossref","is-referenced-by-count":26,"title":["Evaluation of the Effect of Two Dose Rates of Cyclosporine on the Severity of Perianal Fistulae Lesions and Associated Clinical Signs in Dogs"],"prefix":"10.1111","volume":"35","author":[{"given":"ARTHUR K.","family":"HOUSE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAVIER","family":"GUITIAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUSAN P.","family":"GREGORY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROBERT J.","family":"HARDIE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.2460\/javma.1995.206.11.1680","article-title":"Treatment of perianal fistulas in dogs","volume":"206","author":"Ellison GW","year":"1995","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1973.tb06467.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1975.tb05760.x"},{"key":"e_1_2_6_5_2","first-page":"575","article-title":"Anal furunculosis","volume":"21","author":"Houlton JEF","year":"1980","journal-title":"a review of seventy cases"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2002.tb00039.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1992.tb01062.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1993.tb02726.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.153.12.354"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02090211"},{"key":"e_1_2_6_11_2","first-page":"39","article-title":"Cyclosporine treatment of perianal fistulas in dogs","volume":"8","author":"Mathews KA","year":"1997","journal-title":"Can Vet J"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-8411(92)90031-K"},{"key":"e_1_2_6_13_2","first-page":"73","volume-title":"Current Veterinary Therapy XII","author":"Vaden SL","year":"1995"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.37.020186.001243"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600830336"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1994.tb00494.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.2460\/javma.1997.211.10.1249","article-title":"Randomized controlled trial of cyclosporine for treatment of perianal fistulas in dogs","volume":"211","author":"Mathews KA","year":"1997","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_6_18_2","first-page":"569","article-title":"Cyclosporine as the sole treatment for anal furunculosis","volume":"40","author":"Griffiths LG","year":"1999","journal-title":"preliminary results"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.152.8.225"},{"key":"e_1_2_6_20_2","unstructured":"WooldridgeJD GregoryCR MathewsKG: Clinical evaluation of the efficacy of leflunamide alone leflunamide and cyclosporine and cyclosporine at varying dosages in the treatment of perianal fistulas in dogs. 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