{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:36:02Z","timestamp":1789216562179,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T00:00:00Z","timestamp":1335744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the feasibility and safety of transplantation of autologous bone marrow stromal cell (<jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>) in dogs with acute spinal cord injury (<jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>An open\u2010label single\u2010arm trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Dogs (n = 7) with severe SCI from <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>6 to <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>5, caused by vertebral fracture and luxation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Decompressive and stabilization surgery was performed on dogs with severe SCI caused by vertebral fracture and luxation. Autologous <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s were obtained from each dog's femur, cultured, and then injected into the lesion in the acute stage. Adverse events and motor and sensory function were observed for &gt;1 year after <jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Follow\u2010up was 29\u201362 months after <jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content>. No complications (eg, infection, neuropathic pain, worsening of neurologic function) were observed. Two dogs walked without support, but none of the 7 dogs had any change in sensory function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Autologous <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content> transplantation is feasible and safe in dogs with acute SCI. 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