{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T03:50:06Z","timestamp":1794541806483,"version":"4.9.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,3,4]],"date-time":"2011-03-04T00:00:00Z","timestamp":1299196800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2003<\/jats:bold> To compare the efficacy of oxygen\u2010ozone therapy and the combined use of oxygen\u2010ozone therapy with percutaneous intradiscal radiofrequency thermocoagulation (PIRFT) for the treatment of contained lumbar disc herniation.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Ninety\u2010one adult patients with low back pain secondary to contained lumbar disc herniation were randomly assigned into two groups. Ozone group received intradiscal oxygen\u2010ozone therapy (4 to 7\u2003mL of oxygen ozone mixture); ozone\u2010PIRFT group received a combination of oxygen\u2010ozone therapy with PIRFT (radiofrequency lesioning at 80\u00b0C for 360\u2003s).<\/jats:p><jats:p><jats:bold>Outcome Measures:\u2003<\/jats:bold> Primary outcome measures included a visual analog scale (VAS) for pain and the Oswestry disability index (ODI). Secondary outcome measures included pain relief, reduction of analgesic consumption, and patient's satisfaction. Clinical assessment of these outcome measures was performed at 2 weeks, 1 month, 3 months, 6 months, and 1 year after the procedure.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> VAS scores and ODI were significantly decreased by both ozone and ozone\u2010PIRFT when compared with the baseline values at all points of follow\u2010up; however, ozone\u2010PIRFT produced a significant reduction in the VAS scores and ODI when compared to ozone at 2 weeks, 1 month, 3 months, 6 months, and 1 year follow\u2010up. Ozone\u2010PIRFT also resulted in a significant change in all secondary measures at all points of follow\u2010up, as compared with the ozone group.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Ozone\u2010PIRFT is more efficacious than ozone alone in reducing pain scores, analgesic consumption, improving functional outcome, and satisfaction of patients with contained lumbar disc herniation.<\/jats:p>","DOI":"10.1111\/j.1533-2500.2010.00409.x","type":"journal-article","created":{"date-parts":[[2010,7,19]],"date-time":"2010-07-19T09:36:44Z","timestamp":1279532204000},"page":"160-166","source":"Crossref","is-referenced-by-count":31,"title":["Comparative Evaluation of Oxygen\u2010Ozone Therapy and Combined Use of Oxygen\u2010Ozone Therapy with Percutaneous Intradiscal Radiofrequency Thermocoagulation for the Treatment of Lumbar Disc Herniation"],"prefix":"10.1111","volume":"11","author":[{"given":"Sujeet","family":"Gautam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Rastogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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