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Pain is one of the most important symptoms of chronic pancreatitis. The pathogenesis of this pain can only partly be explained and it is therefore often difficult to treat this symptom.<\/jats:p><jats:p>The management of pain induced by chronic pancreatitis starts with lifestyle changes and analgesics.<\/jats:p><jats:p>For the pharmacological management, the three\u2010step ladder of the World Health Organization extended with the use of co\u2010analgesics is followed.<\/jats:p><jats:p>Interventional pain management may consist of radiofrequency treatment of the nervi splanchnici, spinal cord stimulation, endoscopic stenting or stone extraction possibly in combination with lithotripsy, and surgery.<\/jats:p><jats:p>To date, there are no randomized controlled trials supporting the efficacy of radiofrequency and spinal cord stimulation. The large published series reports justify a recommendation to consider these treatment options. Radiofrequency treatment, being less invasive than spinal cord stimulation, could be tested prior to considering spinal cord stimulation.<\/jats:p><jats:p>There are several other treatment possibilities such as endoscopic or surgical treatment, pancreatic enzyme supplementation and administration of octreotide and antioxidants. All may have a role in the management of pain induced by chronic pancreatitis.<\/jats:p>","DOI":"10.1111\/j.1533-2500.2011.00474.x","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T03:21:42Z","timestamp":1308280902000},"page":"492-505","source":"Crossref","is-referenced-by-count":31,"title":["26.\u2002Pain in Chronic Pancreatitis"],"prefix":"10.1111","volume":"11","author":[{"given":"Martine","family":"Puylaert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Kapural","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Van Zundert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Peek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"Lataster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagy","family":"Mekhail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"van Kleef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande C. 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