{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T01:34:10Z","timestamp":1774488850797,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,6,16]],"date-time":"2011-06-16T00:00:00Z","timestamp":1308182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Carbamazepine (CBZ) is one of the standard pharmacological treatments for neuropathic pain. However, its serious adverse drug reactions include Stevens\u2013Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Recently, <jats:italic>HLA\u2010B*1502<\/jats:italic> allele was implicated as a genetic marker of CBZ\u2010induced SJS\/TEN in some Asian epilepsy populations.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> This is a case control study to describe the clinical characteristics of SJS\/TEN in Thai patients with neuropathic pain who were treated with CBZ, and to determine the association of <jats:italic>HLA\u2010B*1502<\/jats:italic> in these patients, comparing with those who exposed to CBZ for at least 6\u2003months without any cutaneous reactions.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Thirty\u2010four SJS\/TEN patients and 40 control patients were included in this study. Mean age of SJS\/TEN patients was 47\u2003years. SJS\/TEN was developed in 10.8\u2003\u00b1\u20031.4\u2003days after initiation of CBZ. <jats:italic>HLA\u2010B*1502<\/jats:italic> allele was found in 32 of 34 SJS\/TEN patients (94.1%) but it was found only in 7 of 40 control patients (17.5%). The association was very strong with an odds ratio of 75.4. Sensitivity and specificity of this <jats:italic>HLA\u2010B*1502<\/jats:italic> genotype test were 94.1% and 82.5%, respectively, while the positive predictive value and negative predictive value were 1.43% and 99.98%, respectively. Positive and negative likelihood ratios were 5.37 and 0.07, respectively.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>  <jats:italic>HLA\u2010B*1502<\/jats:italic> is a strong genetic marker for CBZ\u2010induced SJS\/TEN in Thai patients with neuropathic pain. The screening for this marker should be performed prior to initiation of CBZ treatment to assess the risk of this serious side effect.<\/jats:p>","DOI":"10.1111\/j.1533-2500.2011.00479.x","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T03:24:32Z","timestamp":1308281072000},"page":"202-208","source":"Crossref","is-referenced-by-count":95,"title":["<i>HLA\u2010B*1502<\/i> Strongly Predicts Carbamazepine\u2010Induced Stevens\u2013Johnson Syndrome and Toxic Epidermal Necrolysis in Thai Patients with Neuropathic Pain"],"prefix":"10.1111","volume":"12","author":[{"given":"Kongkiat","family":"Kulkantrakorn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wichittra","family":"Tassaneeyakul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somsak","family":"Tiamkao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thawinee","family":"Jantararoungtong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Napat","family":"Prabmechai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suda","family":"Vannaprasaht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pansu","family":"Chumworathayi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paskorn","family":"Sritipsukho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,16]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.02999.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000326598.83183.04"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1993.tb02814.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/157488606777934459"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.01.001"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.12.022"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740330903427969"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04481.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.57718"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02533.x"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01719.x"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2010.08.007"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000199500.46842.4a"},{"key":"e_1_2_8_15_2","unstructured":"FarkasR.Clinical Review Adverse Events of Carbamazepine.2007. 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