{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:55:23Z","timestamp":1781582123140,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T00:00:00Z","timestamp":1085356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>Transfusion of group O single\u2010donor apheresis PLTs (SDP) to group A recipients has resulted in intravascular hemolysis and mortality. Owing to low availability of type\u2010specific SDPs, transfusion services sometimes issue ABO\u2010mismatched PLTs. After observing two cases of acute hemolysis following infusion of O SDPs to group A patients, where both recipient eluates revealed anti\u2010A specificity, a prospective study to determine the prevalence of \u201chigh\u2010titer\u201d anti\u2010A\/A,B in group O SDPs was commenced.<\/jats:p><jats:p>One hundred group O SDP samples were tested. Titers of at least 64 and\/or 256 from either buffered (generally reflective of IgM antibodies) or anti\u2010IgG gel cards, respectively, were considered critically high. Twenty\u2010eight and 39 percent of samples revealed critically high anti\u2010A\/A,B IgM and IgG titers, respectively. IgM titers were at 1:64 (18%), 128 (6%), and 256 (4%), whereas IgG titers were at 1:256 (28%), 512 (7%), 1024 (2%), and 2048 (2%).<\/jats:p><jats:p>The prevalence of critical anti\u2010A\/A,B titers in group O SDPs is relatively high. Thus, the risk of minor side ABO mismatch and potential intravascular hemolysis during group O SDP transfusion to group A recipients may be significant. Based on these data, a policy was instituted to test anti\u2010A\/A,B titers in O SDPs prior to \u201cout\u2010of\u2010group\u201d transfusion.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2004.03290.x","type":"journal-article","created":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T08:51:28Z","timestamp":1085388688000},"page":"805-808","source":"Crossref","is-referenced-by-count":105,"title":["Significant numbers of apheresis\u2010derived group O platelet units have \u201chigh\u2010titer\u201d anti\u2010A\/A,B: implications for transfusion policy"],"prefix":"10.1111","volume":"44","author":[{"given":"C.D.","family":"Josephson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.C.","family":"Mullis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Van Demark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.D.","family":"Hillyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,5,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40080902.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830460321"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1001\/jama.1987.03390130095036","article-title":"Consensus conference: platelet transfusion therapy","volume":"257","year":"1987","journal-title":"JAMA"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1988.28588337323.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/109.6.769"},{"key":"e_1_2_6_7_2","volume-title":"High titre Anti\u2010A\/B testing of donors within the National Blood Service (NBS) (Internet).","author":"MacLennan S","year":"2002"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/23.8_ts.828"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.1966.tb04751.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(52)91548-1"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/16.3.193"},{"key":"e_1_2_6_12_2","volume-title":"Use and abuse of the precautionary principle (Internet)","author":"Saunders P","year":"2003"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1998.38198141498.x"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1537-2995.2004.03290.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1537-2995.2004.03290.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1537-2995.2004.03290.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T02:47:04Z","timestamp":1697251624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1537-2995.2004.03290.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,24]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1111\/j.1537-2995.2004.03290.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1537-2995.2004.03290.x","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5,24]]}}}