{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:31:38Z","timestamp":1758817898430},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,3,24]],"date-time":"2004-03-24T00:00:00Z","timestamp":1080086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold>Management of patients with clinically significant anti\u2010IgA is difficult and unsatisfactory in many aspects.<\/jats:p><jats:p><jats:bold>PATIENTS AND METHOD:<\/jats:bold>A 40\u2010year\u2010old man with common variable immunodeficiency had a previous history of anaphylaxis after an intramuscular immuno\u2010 globulin administration. His serum contained anti\u2010IgA, and he required immunoglobulins for recurrent infections.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold>The administration of intravenous immuno\u2010 globulins (IVIgG) containing less than 0.1\u2003mg per mL IgA led to an anaphylactic reaction after the transfusion of only 2 to 3\u2003mL. The same IVIgG charge was subsequently pretreated with freshly separated autologous plasma and given to the patient on three consecutive days without any reaction (1.25, 10, and 10\u2003g each in 400\u2003mL plasma). Anti\u2010IgA activity did not increase, and the patient was treated again without complications.<\/jats:p><jats:p><jats:bold>DISCUSSION:<\/jats:bold>Ex vivo pretreatment of IVIgG preparations with autologous plasma appears to be safe and useful in the management of patients with clinically significant anti\u2010IgA. To achieve a significant IgA blockage, the preparation to be used should not contain large amounts of IgA.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold>The strategy described here appears to be safe and may help prevent anaphylaxis in many instances.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2004.03316.x","type":"journal-article","created":{"date-parts":[[2004,3,24]],"date-time":"2004-03-24T09:39:01Z","timestamp":1080121141000},"page":"509-511","source":"Crossref","is-referenced-by-count":16,"title":["A new strategy for the prevention of IgA anaphylactic transfusion reactions"],"prefix":"10.1111","volume":"44","author":[{"given":"Abdulgabar","family":"Salama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Temmesfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Hippenstiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Kalus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Suttorp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Kiesewetter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,24]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"1442","volume":"316","year":"1998","journal-title":"Ewan PW. 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