{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T14:07:04Z","timestamp":1744207624509},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,7,20]],"date-time":"2004-07-20T00:00:00Z","timestamp":1090281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p><jats:bold>BACKGROUND:\u2002<\/jats:bold> Increasing concern about transfusion transmission of variant Creutzfeldt\u2010Jakob disease has resulted in indefinite deferral of transfused donors in France and the UK. Little is known, however, about the impact of indefinite deferral of transfused donors on blood safety and availability in the US.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:\u2002<\/jats:bold> Data were collected on allogeneic donations at five US blood centers during 1991 through 2000. Donation characteristics, prevalence, and incidence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) were compared between transfused and nontransfused donors. Unreported deferrable risk (UDR) and reasons to donate were evaluated with data from a mail survey.<\/jats:p><jats:p><jats:bold>RESULTS:\u2002<\/jats:bold> Transfusion history was reported by 4.2 percent of donors. Prevalence and incidence of HIV and HBV were comparable between transfused and nontransfused donors. Although HCV incidence was similar in both groups, HCV prevalence was nearly three times higher in transfused than in nontransfused first\u2010time donors. UDR and reasons to donate were similar in the two groups, except transfused donors were less likely to donate for screening test results (odds ratio, 0.5; 95% confidence interval, 0.3\u20100.8).<\/jats:p><jats:p><jats:bold>CONCLUSION:\u2002<\/jats:bold> Transfused and nontransfused donors had similar viral incidence and comparable UDR, suggesting that indefinite deferral of transfused donors would unlikely improve blood safety. Until more is known about the prevalence and transfusion transmissibility of emerging agents, indefinite deferral of previously transfused donors in the US does not appear warranted.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2004.04034.x","type":"journal-article","created":{"date-parts":[[2004,7,20]],"date-time":"2004-07-20T11:58:25Z","timestamp":1090324705000},"page":"1243-1251","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of demographic and donation profiles and transfusion\u2010transmissible disease markers and risk rates in previously transfused and nontransfused blood donors"],"prefix":"10.1111","volume":"44","author":[{"given":"B.","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kleinman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.B.","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.L.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.A.","family":"Glynn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.J.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.C.","family":"Nass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.P.","family":"Busch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"For The","family":"Retrovirus Epidemiology Donor Study","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,20]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"33","volume-title":"Blood safety in the new millennium.","author":"Busch MP.","year":"2001"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-10-199711150-00009"},{"key":"e_1_2_7_4_2","first-page":"S81","article-title":"Prevention of HIV transmission by blood transfusion in the developing world: achievements and continuing challenges","volume":"12","author":"Lackritz EM.","year":"1998","journal-title":"AIDS"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)06318-1"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400606"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15486-X"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2002.tb05331.x"},{"key":"e_1_2_7_9_2","volume-title":"CJD fears prompt blood donor ban (Internet).","year":"2004"},{"key":"e_1_2_7_10_2","unstructured":"America's Blood Centers.Blood shortages strain national supply leaving many parts of the country with less than a one\u2010day supply.ABC Newsletter2003 Jan 17:1\u20102."},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1995.351196110900.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199606273342601"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.2.229"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41060736.x"},{"key":"e_1_2_7_15_2","first-page":"106S","article-title":"A proposed new method to estimate hepatitis B incidence rates based on HBsAg marker","volume":"39","author":"Wright DJ","year":"1999","journal-title":"Transfusion"},{"key":"e_1_2_7_16_2","first-page":"88","volume-title":"Fundamentals of Biostatistics","author":"Rosner B.","year":"1990"},{"key":"e_1_2_7_17_2","volume-title":"WESVAR PC.","year":"2000"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2003.00660.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260711"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/tm.2000.7353"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2001.00006.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1990.30590296381.x"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1977.17277151916.x"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199606273342602"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310329"},{"key":"e_1_2_7_26_2","doi-asserted-by":"crossref","unstructured":"BuschMP KleinmanSH NemoGJ.Current and emerging infectious risks of blood transfusions. 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