{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T04:55:55Z","timestamp":1697345755077},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,1,19]],"date-time":"2005-01-19T00:00:00Z","timestamp":1106092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p><jats:bold>BACKGROUND:\u2002<\/jats:bold> Allogeneic transplantation in elderly patients requires a dose\u2010reduced conditioning regimen. Owing to reduced\u2010intensity conditioning, host\u2010 and donor\u2010type immune responses may affect the early posttransplant period, whereas only later on donor\u2010derived reactions may ensue. Mismatches in the HLA system are known to be detrimental for the outcome of transplantation. Mismatches between donor and recipient for human platelet antigens (HPAs) may also affect the success of transplantation owing to serving as minor histocompatibility antigens and therefore rendering recipients at risk for graft\u2010versus\u2010host disease (GVHD) or graft rejection and inhibition of thrombopoiesis attributed to platelet (PLT) antibodies.<\/jats:p><jats:p><jats:bold>PATIENTS AND METHODS:\u2002<\/jats:bold> Therefore, the occurrence of GVHD, incidence of relapse, need of PLT support, and outcome by analysis of 45 donor\u2010recipient pairs for HPA\u20101, \u20102, \u20103, and \u20105 allotypes and screening for PLT antibodies were evaluated before transplantation and again 1\u2003year thereafter.<\/jats:p><jats:p><jats:bold>RESULTS:\u2002<\/jats:bold> Mismatches within the HPA system were not associated with an increased occurrence of transplant\u2010related mortality or GVHD, the onset of thrombopoiesis, the frequency of PLT transfusions, or the incidence of relapse. Neither were settings of homozygous donors versus heterozygous recipients (graft\u2010vs.\u2010host direction) nor homozygous recipients versus heterozygous donors (host\u2010vs.\u2010graft direction) associated with any adverse effects on the outcome of the transplantation.<\/jats:p><jats:p><jats:bold>CONCLUSION:\u2002<\/jats:bold> Thus, the HPA match does not affect the outcome of transplantation after reduced\u2010intensity conditioning.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2004.04115.x","type":"journal-article","created":{"date-parts":[[2005,1,19]],"date-time":"2005-01-19T14:28:27Z","timestamp":1106144907000},"page":"195-201","source":"Crossref","is-referenced-by-count":7,"title":["The influence of human platelet antigen match on the success of allogeneic peripheral blood progenitor cell transplantation following a reduced\u2010intensity conditioning regimen"],"prefix":"10.1111","volume":"45","author":[{"given":"Gerda 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