{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:13:40Z","timestamp":1761822820361},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,8,12]],"date-time":"2005-08-12T00:00:00Z","timestamp":1123804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p><jats:bold>BACKGROUND:\u2002<\/jats:bold> Given the increasing use of intravenous immunoglobulin (IVIG) for various neurologic conditions and uncertainty pertaining to its benefits and harms, a systematic review was conducted of randomized controlled trials (RCTs) evaluating IVIG for all neurologic indications for which there was at least one published trial.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:\u2002<\/jats:bold> For this systematic review, a systematic search strategy was applied to MEDLINE (1966\u2010June 2003) and the Cochrane Register of Controlled Trials (June 2003) to identify potentially eligible RCTs comparing IVIG to placebo or an active control. All dosage regimens were considered. Abstracts were excluded, and no restriction was placed on language of publication. Two investigators independently performed data extraction with a standardized form. Measures of effect were calculated for each trial independently, and studies were pooled based on clinical and methodologic judgment as to its appropriateness. Where pooling of trials was inappropriate, a qualitative discussion of findings is provided.<\/jats:p><jats:p><jats:bold>RESULTS AND CONCLUSIONS:\u2002<\/jats:bold> Thirty\u2010seven trials representing 14 conditions were identified. IVIG is more effective than placebo for treatment of relapsing\u2010remitting multiple sclerosis and idiopathic chronic inflammatory demyelinating polyneuropathy. There is also potential benefit for treatment of multifocal motor neuropathy, myasthenia gravis, dermatomyositis, stiff\u2010person syndrome, and Lambert\u2010Eaton myasthenic syndrome. There was insufficient evidence to determine whether IVIG therapy was more effective than plasma exchange for Guillain\u2010Barr\u00e9 syndrome. There was also insufficient evidence regarding paraprotein\u2010associated polyneuropathy. No evidence of benefit was observed for secondary progressive multiple sclerosis or inclusion body myositis.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2005.00581.x","type":"journal-article","created":{"date-parts":[[2005,9,19]],"date-time":"2005-09-19T15:28:21Z","timestamp":1127143701000},"page":"1640-1657","source":"Crossref","is-referenced-by-count":32,"title":["Use of intravenous immunoglobulin for treatment of neurologic conditions: a systematic review"],"prefix":"10.1111","volume":"45","author":[{"given":"Dean","family":"Fergusson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Hutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Tinmouth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumanan","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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