{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:44:07Z","timestamp":1792003447534,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T00:00:00Z","timestamp":1125014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>\n                    <jats:bold>BACKGROUND:<\/jats:bold>\n                    The D antigen includes category D, partial D, and weak D types, which are important because anti\u2010D alloimmunization can occur in some but not all persons that express a variant\n                    <jats:italic>RHD<\/jats:italic>\n                    allele. At present, there is little prospective information on the prevalence of D variants among obstetric patients and potential transfusion recipients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold>\n                    The\n                    <jats:italic>RHD<\/jats:italic>\n                    alleles were prospectively examined in a large patient population identified on the basis of a difference in anti\u2010D reactivity between two reagents.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    Fifty\u2010five discrepancies (0.96% of D\u2013) were noted among 33,864 ethnically diverse patients over 18\u2003months, of which 54 represented mutated\n                    <jats:italic>RHD<\/jats:italic>\n                    alleles. Seven obstetric patients were assigned D\u2013 status based on serology; only 1 patient had a partial\n                    <jats:italic>RHD<\/jats:italic>\n                    allele. Ten of 25 (36%) obstetric patients and 4 of 6 (67%) female potential transfusion recipients of childbearing age or younger were assigned D+ status, and they expressed a D variant known to permit anti\u2010D alloimmunization. In total 20\n                    <jats:italic>RHD<\/jats:italic>\n                    alleles were identified including category,\n                    <jats:italic>DVa<\/jats:italic>\n                    or\n                    <jats:italic>DVa<\/jats:italic>\n                    \u2010like alleles (n\u2003=\u20037),\n                    <jats:italic>DAR<\/jats:italic>\n                    (n\u2003=\u20038), and four novel\n                    <jats:italic>RHD<\/jats:italic>\n                    alleles including two new\n                    <jats:italic>DAU<\/jats:italic>\n                    alleles.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION:<\/jats:bold>\n                    Given the complexity of D antigen expression, it is concluded that some clinically important D variants identified by standard serologic analysis phenotype as D+ and are potentially at risk for the development of anti\u2010D.\n                  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