{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:57:23Z","timestamp":1793645843204,"version":"4.5.1"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,10,3]],"date-time":"2005-10-03T00:00:00Z","timestamp":1128297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold>Patients with hematologic malignancies often require blood products, and parvovirus B19 is known to be transmitted by this route. Primary infection with parvovirus B19 shows a wide variety of disease manifestation. In immunocompromised patients, symptoms are severe and viral clearance is delayed or missing.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold>A total of 2123 blood products given to all patients of a hematologic ward over a period of 6\u2003months were retrospectively examined for the presence of parvovirus B19 DNA by an in\u2010house real\u2010time polymerase chain reaction (PCR; TaqMan). Patients who had received B19 DNA\u2013positive blood products were further investigated serologically and by PCR for the presence of parvovirus B19 antibodies and DNA.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold>Twenty\u2010one (1%) of 2123 blood products tested positive for the presence of B19 DNA (2% of pooled products, 0.7% of single\u2010donor products, and 17.6% of allogeneic peripheral blood progenitor cells), the median viral load was 700 genome equivalents per mL. During the study period, 114 patients were treated on the ward, and 14 (12%) of them received B19 DNA\u2013positive blood components. None of them developed symptoms of an acute B19 infection, although one had a short low\u2010level viremia.<\/jats:p><jats:p><jats:bold>CONCLUSIONS:<\/jats:bold>Although B19 DNA was detected in 1\u2003percent of blood products given to hematologic patients, the exposure of 12\u2003percent of patients did not result in symptomatic infections.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2005.00610.x","type":"journal-article","created":{"date-parts":[[2005,10,3]],"date-time":"2005-10-03T09:24:55Z","timestamp":1128331495000},"page":"1811-1815","source":"Crossref","is-referenced-by-count":38,"title":["Exposure of hematologic patients to parvovirus B19 as a contaminant of blood cell preparations and blood 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