{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:39:56Z","timestamp":1761154796647},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,5,3]],"date-time":"2005-05-03T00:00:00Z","timestamp":1115078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Prestorage pooling of whole blood\u2013derived platelets (PLTs) would simplify bacterial detection. This study evaluated the in vivo effect of the prestorage pooling of PLTs stored for up to 5\u2003days, by assessing the corrected count increment (CCI) 18 to 24\u2003hours after transfusion of the product.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> A randomized block noninferiority design was used. Eligible patients had chemotherapy\u2010induced thrombocytopenia and were considered likely to need at least six PLT transfusions. For every block of two transfusion events, one consisted of PLTs stored individually and then pooled before transfusion, and the other was a product pooled before storage. The primary outcome was categorized as a successful (&gt;4.5) or unsuccessful (\u22644.5) 18\u2010 to 24\u2010hour posttransfusion CCI analyzed with a matched pair score test. A mixed\u2010effect linear model estimated the mean difference in CCI between the two types of storage.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Twenty\u2010three eligible patients received a total of 189 PLT transfusions. The median number of PLT transfusions was 7 (range, 0\u201027). Eighty\u2010five complete transfusion pairs were used in the primary analysis. The proportions of transfusions leading to a CCI of greater than 4.5 was identical for both routine and PLTs pooled before storage (45\/85\u2003=\u200352.9%; relative risk, 1.00; lower limit of the one\u2010sided 95% confidence interval [CI], 0.83). The estimate of the mean difference in CCI between pooled and routine storage (pooled\u2003\u2212\u2003routine) was \u22120.45 (95% CI, \u22122.23 to 1.33; p\u2003=\u20030.63).<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> These results provide evidence that storage of PLTs as a pool for up to 5\u2003days results in posttransfusion CCIs that are not inferior to PLTs stored individually.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2005.04233.x","type":"journal-article","created":{"date-parts":[[2005,6,20]],"date-time":"2005-06-20T23:21:15Z","timestamp":1119309675000},"page":"896-903","source":"Crossref","is-referenced-by-count":22,"title":["Assessing the effectiveness of whole blood\u2013derived platelets stored as a pool: a randomized block noninferiority trial"],"prefix":"10.1111","volume":"45","author":[{"given":"N.M.","family":"Heddle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.J.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Blajchman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.L.","family":"Barty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.S.","family":"Sigouin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.M.","family":"Boye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.J.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.G.","family":"Kelton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,31]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"180","volume-title":"AABB 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