{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:08:33Z","timestamp":1794002913892,"version":"4.8.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,4,6]],"date-time":"2005-04-06T00:00:00Z","timestamp":1112745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Isohemagglutinins directed against the donor blood group frequently delay erythroid engraftment after major ABO\u2010mismatched allogeneic hematopoietic progenitor cell transplantation (HPCT). Graft\u2010versus\u2010host reactions are capable of accelerating the clearance of isohemagglutinins. Whether immunogenicity of the A\u2010 and B\u2010antigen is important in this process is unknown.<\/jats:p><jats:p><jats:bold>PATIENTS AND METHODS:<\/jats:bold> Data of 807 patients from three centers were screened for patients with major or bidirectionally ABO\u2010mismatched donors. Clinical data and red blood cell (RBC) transfusion support were analyzed retrospectively.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> A total of 158 patients with major or bidirectionally mismatched donors were identified. After major mismatched HPCT, patients with anti\u2010A directed against the donor blood group required RBC transfusion support for a median of 109\u2003days (range, 0\u2010324\u2003days) compared to 21\u2003days (range, 2\u201098\u2003days) for patients with anti\u2010B directed against donor blood group (log\u2010rank test, p\u2003=\u20030.0001). Other risk factors associated with prolonged RBC transfusion support in univariate analysis were age (p\u2003=\u20030.024), cytomegalovirus infection (p\u2003=\u20030.016), hemolytic anemia (p\u2003=\u20030.027), and chronic bleeding disorders (p\u2003=\u20030.038). The independent influence of donor blood group and recipient age were confirmed in a multivariate analysis.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> These results indicate that the immunogenicity of the ABO antigen plays an important role for the kinetics of erythroid engraftment after ABO\u2010mismatched HPCT.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2005.04236.x","type":"journal-article","created":{"date-parts":[[2005,4,21]],"date-time":"2005-04-21T23:18:22Z","timestamp":1114125502000},"page":"779-787","source":"Crossref","is-referenced-by-count":18,"title":["After major ABO\u2010mismatched allogeneic hematopoietic progenitor cell transplantation, erythroid engraftment occurs later in patients with donor blood group A than donor blood group B"],"prefix":"10.1111","volume":"45","author":[{"given":"Johannes","family":"Schetelig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Breitschaft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaus","family":"Kr\u00f6ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Zabelina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Ebell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bornh\u00e4user","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Haack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Ehninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulgabar","family":"Salama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Siegert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Cooperative Transplantations Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40050543.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703621"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.5.1477.1477"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1182\/blood.V75.1.290.290","article-title":"Pure red cell aplasia of long duration complicating major ABO\u2010incompatible bone marrow transplantation","volume":"75","author":"Gmur JP","year":"1990","journal-title":"Blood"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198803000-00005"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198204000-00017"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.3.1150"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1992.tb01194.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702121"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.6.1687"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03905.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03693.x"},{"key":"e_1_2_6_14_2","first-page":"825","article-title":"1994 Consensus conference on acute GVHD grading","volume":"15","author":"Przepiorka D","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_6_15_2","first-page":"247","article-title":"Consensus among bone marrow transplanters for diagnosis, grading and treatment of chronic graft\u2010versus\u2010host disease. 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