{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:06:16Z","timestamp":1769598376916,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,5,3]],"date-time":"2005-05-03T00:00:00Z","timestamp":1115078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Most studies indicate that the incidence of graft\u2010versus\u2010host disease (GVHD) is not increased in ABO\u2010mismatched allogeneic peripheral blood progenitor cell transplantation. These studies exclusively looked at ABO phenotypes without considering the fact that different genotypes hide behind identical phenotypes that encode for different sets of glycosyltransferases, thus providing a source for minor histocompatibility antigens (mHags).<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> Therefore, whether peptides derived from ABO glycosyltransferases are capable of stimulating peptide\u2010specific T cells was investigated. T\u2010cell responses were identified by measuring intracellular interleukin\u20102 expression.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Individuals with <jats:italic>ABO<\/jats:italic> genotypes encoding glycosyltransferases lacking the peptide sequences used for stimulation showed T\u2010cell responses, whereas those expressing glycosyltransferases containing the respective peptide sequences proved to be tolerant, indicating that ABO peptides are allogeneic and may act as mHags. Interestingly, even <jats:italic>ABO<\/jats:italic>*<jats:italic>O<\/jats:italic> individuals were tolerant to O\u2003glycosyltransferase\u2013derived peptides, which strongly suggests that truncated O transferases are expressed.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> Considering allelic ABO sequences, at least 15\u2003percent of all phenotypically ABO\u2010matched transplant pairs can be expected to have genotype constellations relevant to GVHD. Therefore, the genotype behind the ABO blood group phenotype should be considered to answer the question of whether ABO mismatch is a risk factor of GVHD.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2005.04370.x","type":"journal-article","created":{"date-parts":[[2005,6,20]],"date-time":"2005-06-20T23:21:15Z","timestamp":1119309675000},"page":"960-968","source":"Crossref","is-referenced-by-count":21,"title":["ABO glycosyltransferases as potential source of minor histocompatibility antigens in allogeneic peripheral blood progenitor cell transplantation"],"prefix":"10.1111","volume":"45","author":[{"given":"Britta","family":"Eiz\u2010Vesper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Seltsam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Blasczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,31]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"159","article-title":"Immunohematologic complications of bone marrow transplantation","volume":"8","author":"Klumpp TR","year":"1991","journal-title":"Bone Marrow 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