{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:41:06Z","timestamp":1775065266903,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,14]],"date-time":"2005-12-14T00:00:00Z","timestamp":1134518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:bold>BACKGROUND:\u2002<\/jats:bold> The de novo development of anti\u2010D after D\u2010mismatched allogeneic hematopoietic stem cell transplantation (AHSCT) is a possibility that must be considered. The transfusion of D\u2212 blood components after AHSCT has been recommended but anti\u2010D alloimmunization in this setting has been studied little. Thus, the aim of this study was to analyze anti\u2010D formation after D\u2010mismatched AHSCT.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:\u2002<\/jats:bold> Thirty patients with a hematologic disease who underwent D\u2010mismatched AHSCT were retrospectively studied. Support therapy included red blood cells (RBCs) and platelet (PLT) concentrates (PCs) from whole\u2010blood donations and PLTs from apheresis. After AHSCT, patients received D+ PCs without administering Rh immunoglobulin (RhIG). An antibody screening to detect anti\u2010D was performed by low\u2010ionic\u2010strength saline\u2010indirect antiglobulin test with the tube test.<\/jats:p><jats:p><jats:bold>RESULTS:\u2002<\/jats:bold> Fifteen D+ patients received stem cells (SCs) of D\u2212 donors and 15 D\u2212 patients received SCs of D+ donors. After AHSCT, patients received a median of 11.5 (range, 0\u201032) D\u2212 RBC units. D+ patients received 682 (83%) of 825 PLT units from D+ donors, and D\u2212 patients received 573 (85%) of 678 PLT units from D+ donors. None of the 30 patients developed anti\u2010D after a median follow\u2010up of 32\u2003weeks (range, 4\u2010310\u2003weeks).<\/jats:p><jats:p><jats:bold>CONCLUSION:\u2002<\/jats:bold> Anti\u2010D alloimmunization after performing a D\u2010mismatched AHSCT is infrequent in patients with hematologic diseases although patients receive D\u2212mismatched PLT transfusions without RhIG administration.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2006.00698.x","type":"journal-article","created":{"date-parts":[[2005,12,14]],"date-time":"2005-12-14T14:57:00Z","timestamp":1134572220000},"page":"169-173","source":"Crossref","is-referenced-by-count":26,"title":["Anti\u2010D alloimmunization after D\u2010mismatched allogeneic hematopoietic stem cell transplantation in patients with hematologic diseases"],"prefix":"10.1111","volume":"46","author":[{"given":"Joan","family":"Cid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Fern\u00e1ndez\u2010Avil\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enric","family":"Carreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Mazzara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antorio","family":"Ordinas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"159","article-title":"Immunohematologic 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