{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:56:41Z","timestamp":1791295001436,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,26]],"date-time":"2006-01-26T00:00:00Z","timestamp":1138233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:bold>BACKGROUND:\u2002<\/jats:bold>  <jats:italic>Trypanosoma cruzi<\/jats:italic>, the protozoan cause of Chagas disease, causes life\u2010long infection and is easily transmitted by blood transfusion. Our goals were to determine the prevalence of Chagas disease among donors in five Mexican blood banks, to look for evidence of transmission of <jats:italic>T. cruzi<\/jats:italic> by transfusion, and to evaluate two serologic assays for Chagas disease.<\/jats:p><jats:p><jats:bold>STUDY DESIGN and METHODS:\u2002<\/jats:bold> Blood samples from donors were tested initially with the Abbott Chagas EIA or the Meridian Chagas\u2019 IgG ELISA. Samples giving readings that were at least 50% of the cutoffs were run in a confirmatory radioimmune precipitation assay (RIPA), as were samples from recipients of blood products from RIPA\u2010positive donors.<\/jats:p><jats:p><jats:bold>RESULTS:\u2002<\/jats:bold> The overall prevalence of Chagas disease was 1\/133 (55\/7,296; 0.75%). In addition, 4 of 9 surviving recipients of blood products from <jats:italic>T. cruzi<\/jats:italic>\u2010infected donors were in turn infected. Using the manufacturers\u2019 recommended cutoffs, the sensitivity and specificity of the Abbott test were 92.0% (23\/25) and 99.8% (2,865\/2,872) respectively, and the corresponding values for the Meridian assay were 70.0% (21\/30) and 100.0% (4,369\/4,369).<\/jats:p><jats:p><jats:bold>CONCLUSIONS:\u2002<\/jats:bold> These findings indicate clearly that transfusion\u2010associated transmission of <jats:italic>T. cruzi<\/jats:italic> is occurring in the study areas. Serologic testing of blood donors for Chagas disease should be performed there and in the rest of Mexico. The two screening assays evaluated may lack the accuracy necessary for blood donor testing when used as suggested by the manufacturers.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2006.00715.x","type":"journal-article","created":{"date-parts":[[2006,1,26]],"date-time":"2006-01-26T14:55:07Z","timestamp":1138287307000},"page":"298-304","source":"Crossref","is-referenced-by-count":75,"title":["Transfusion\u2010associated Chagas disease (American trypanosomiasis) in Mexico: implications for transfusion medicine in the United States"],"prefix":"10.1111","volume":"46","author":[{"given":"Louis 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