{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:23:51Z","timestamp":1789025031812,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p><jats:bold>BACKGROUND:\u2002<\/jats:bold> The severity of hemolytic disease of the newborn (HDN) due to Diego<jats:sup>b<\/jats:sup> (Di<jats:sup>b<\/jats:sup>) mismatch ranges from no symptoms to severe jaundice that requires exchange transfusion (ET). The clinical significance of anti\u2010Di<jats:sup>b<\/jats:sup> is incompletely recognized.<\/jats:p><jats:p><jats:bold>CASE REPORT:\u2002<\/jats:bold> A male newborn, referred with jaundice, was revealed to have HDN due to Di<jats:sup>b<\/jats:sup> mismatch and was treated successfully with phototherapy and high\u2010dose intravenous gamma globulin (IVGG).<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:\u2002<\/jats:bold> The literature of HDN caused by Di<jats:sup>b<\/jats:sup> mismatch was reviewed. The cases were classified into three groups according to their severity: the mildest needed no therapy (NO), the moderate group received phototherapy alone (PHOTO), and the most severe was treated with ET and\/or high\u2010dose IVGG therapy plus phototherapy (ET\/IVGG).<\/jats:p><jats:p><jats:bold>RESULTS:\u2002<\/jats:bold> Among 27 cases of HDN due to Di<jats:sup>b<\/jats:sup> reported to date, 10, 6, and 11 cases required NO, PHOTO, and ET\/IVGG, respectively. A significant correlation (p\u2003&lt;\u20030.01) was found between the maternal anti\u2010Di<jats:sup>b<\/jats:sup> titer and the severity of the disease when the ET\/IVGG group was compared with the NO group. All mothers of the group that needed ET\/IVGG had an anti\u2010Di<jats:sup>b<\/jats:sup> titer of 64 or greater.<\/jats:p><jats:p><jats:bold>CONCLUSION:\u2002<\/jats:bold> A maternal high titer (\u226564) of anti\u2010Di<jats:sup>b<\/jats:sup> is associated with a higher risk of severe hyperbilirubinemia for mismatched newborns.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2006.00743.x","type":"journal-article","created":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T11:59:16Z","timestamp":1141214356000},"page":"454-460","source":"Crossref","is-referenced-by-count":22,"title":["Hemolytic disease of the newborn due to anti\u2010Di<sup>b<\/sup>: a case study and review of the 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