{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:28:27Z","timestamp":1792290507136,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T00:00:00Z","timestamp":1153872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Although living kidney donors are increasingly being used, in most centers, 30 to 40\u2003percent of potential donors are being turned down due to ABO mismatch. A protocol for ABO\u2010mismatched kidney transplantation without splenectomy and with antigen\u2010specific adsorption of ABO antibodies instead of nonspecific plasmapheresis was therefore designed.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> The immunosuppressive protocol used at the Department of Transplantation Surgery, Karolinska University Hospital, Stockholm, Sweden, together with relevant clinical data for 11 of the studied patients, have been described previously. The protocol called for immunoadsorption of ABO antibodies on Days \u22126, \u22125, \u22122, and \u22121 and on Days\u2003+2, +5, and +8. Patient plasma was recirculated through a new apheresis filter, the Glycosorb ABO column (Glycorex Transplantation AB), containing synthetic terminal trisaccharide A or B blood group antigen linked to a Sepharose matrix.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Since 2001, 15 patients, including 2 infants, have been successfully transplanted with ABO\u2010mismatched kidneys from living donors. The donor\u2010recipient blood groups were A1\u2010O (n\u2003=\u20035), A2\u2010O (n\u2003=\u20032), B\u2010O (n\u2003=\u20034), B\u2010A (n\u2003=\u20032), and A1B\u2010B (n\u2003=\u20032). ABO antibody titers at transplantation did not exceed immunoglobulin G 4 or immunoglobulin M 4 levels. No humoral rejections and no late rebound of ABO antibodies were observed. No adverse effects related to immunoadsorption treatment have been recorded.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> It is concluded that ABO\u2010mismatched kidney transplantations can be successfully performed without splenectomy and that ABO antibodies can be effectively and safely depleted with the Glycosorb ABO column.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2006.00927.x","type":"journal-article","created":{"date-parts":[[2006,9,4]],"date-time":"2006-09-04T14:58:40Z","timestamp":1157381920000},"page":"1568-1575","source":"Crossref","is-referenced-by-count":75,"title":["Clinical experience with a new apheresis filter that specifically depletes ABO blood group antibodies"],"prefix":"10.1111","volume":"46","author":[{"given":"Gunilla","family":"Kumlien","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbeth","family":"Ullstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Losvall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars\u2010Gunnar","family":"Persson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Tyd\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2001.00313.x"},{"key":"e_1_2_5_3_2","volume-title":"ABO\u2010incompatible kidney transplantation.","author":"Takahashi K","year":"2001"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000058226.39732.32"},{"key":"e_1_2_5_5_2","first-page":"4538","article-title":"Present experiences in a series of 26 ABO\u2010incompatible living donor renal allografts","volume":"19","author":"Alexandre GP","year":"1987","journal-title":"Transplant Proc"},{"key":"e_1_2_5_6_2","first-page":"273","article-title":"Risks and safety practices in hemapheresis procedures","volume":"113","author":"Huestis DW","year":"1989","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_7_2","first-page":"147","article-title":"Coagulation disorders with plasma exchange","volume":"3","author":"Simon T","year":"1982","journal-title":"Plasma Ther Transfus Technol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000078622.43689.D4"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00653.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470987018"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00147-004-0775-7"},{"key":"e_1_2_5_12_2","volume-title":"Technical manual.","author":"Brecher M","year":"2003"},{"key":"e_1_2_5_13_2","first-page":"88","article-title":"The specific distribution of glycolipid\u2010based blood group A antigens in human kidney related to A1\/A2, Lewis, and secretor status of single individuals. 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