{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:52:22Z","timestamp":1785423142004,"version":"3.56.0"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T00:00:00Z","timestamp":1153872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> This article describes the presence of antibodies against glutathione <jats:italic>S<\/jats:italic>\u2010transferase T1 (GSTT1) in a group of patients who never received a solid organ graft. These antibodies have been previously detected in liver and kidney transplant subjects with donor\u2010recipient mismatch for this enzyme at the genetic level. In liver\u2010grafted subjects, the appearance of these antibodies correlated with de novo immune hepatitis.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> To obtain some insights in this phenomenon, the clinical records of these patients were reviewed, and the possible causes leading to the production of these antibodies and possible clinical consequences were analyzed.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> The clinical situation of these patients was very heterogeneous, but they had in common the need for transfusions or a previous pregnancy. GSTT1 antigen is present in red blood cells, liver, kidney, and other tissues. Because the presence of the <jats:italic>GSTT1\u2010<\/jats:italic>null allele in seven of these patients has been demonstrated, it can be hypothesized that both GSTT1\u2010positive transfusions or pregnancy of a GSTT1\u2010positive fetus could induce these antibodies. Because the recipient is allele\u2010null, no adverse effects in the host are expected to occur. The longest follow\u2010up (5\u2003years) shows no antibody\u2010derived diseases.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> It is concluded that anti\u2010GSTT1 can appear in a context different from the previously published alloreactivity after liver and kidney transplantation, as a consequence of transfusions and pregnancies. So far, no adverse clinical outcomes in our patients have been observed.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2006.00938.x","type":"journal-article","created":{"date-parts":[[2006,9,4]],"date-time":"2006-09-04T14:58:40Z","timestamp":1157381920000},"page":"1505-1509","source":"Crossref","is-referenced-by-count":14,"title":["Antibodies against glutathione <i>S<\/i>\u2010transferase T1 in non\u2013solid organ transplanted patients"],"prefix":"10.1111","volume":"46","author":[{"given":"Ingeborg","family":"Wichmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Aguilera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Bernardos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio\u2003J.","family":"Garc\u00eda N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Vigil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Magari\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Magari\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"N\u00fa\u00f1ez\u2010Rold\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01682.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20209"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3000271"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.04.022"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00901.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.9.4350"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)06478-7"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(00)02826-8"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200102000-00007"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.31167"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(98)00191-9"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1537-2995.2006.00938.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1537-2995.2006.00938.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T16:37:29Z","timestamp":1697301449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1537-2995.2006.00938.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,26]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1537-2995.2006.00938.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1537-2995.2006.00938.x","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,26]]}}}