{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:27:29Z","timestamp":1791124049781,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,8,23]],"date-time":"2006-08-23T00:00:00Z","timestamp":1156291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Hydroxyethyl starch (HES) solutions have largely replaced conventional plasma expanders such as human albumin and colloidal fluids. Only a few side effects have been reported and mainly concern pruritus or blood coagulation disorders. Excessive HES exposure can result in diffuse tissue storage and accumulation with foamy appearing macrophages which produce the enzyme chitotriosidase (CT). In case of massive tissue storage, this enzyme activity can reach levels comparable to those of Gaucher disease.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> In this single\u2010center retrospective analysis of 11 consecutive patients receiving large amounts of HES for chronic plasmapheresis, plasma CT activity was investigated. Five patients receiving chronic intermittent plasmapheresis with conventional plasma expanders served as controls. Plasma CT activity was measured and plotted against creatinine clearance. Where available, marrow aspirate was analyzed with light microscopy to detect foamy macrophages. One patient developed a lysosomal storage disease and was examined extensively.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Conventional plasma expanders did not alter plasma CT activity. In patients with impaired renal function, frequent plasma replacement with HES resulted in an increase in plasma CT activity. In the patient with the acquired lysosomal storage disease, massive tissue infiltration with activated foamy macrophages was observed. The phagocytic capacity in this patient, however, did not seem to be altered.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> Patients with impaired renal function receiving large amounts of HES exhibit an increase in plasma CT activity. Because excessive HES exposure can result in an acquired lysosomal storage disease, this should be avoided in chronic plasmapheresis procedures.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2006.00962.x","type":"journal-article","created":{"date-parts":[[2006,8,23]],"date-time":"2006-08-23T15:01:22Z","timestamp":1156345282000},"page":"1705-1711","source":"Crossref","is-referenced-by-count":48,"title":["Acquired lysosomal storage caused by frequent plasmapheresis procedures with hydroxyethyl starch"],"prefix":"10.1111","volume":"46","author":[{"given":"Johannes J.A.","family":"Auwerda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank W.G.","family":"Leebeek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.H. Paul","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto P.","family":"Van Diggelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King H.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Sonneveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,21]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"283","volume-title":"Hydroxyethyl starch: blood substitutes and plasma expanders.","author":"Thompson WL","year":"1978"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1101(1997)12:3<146::AID-JCA8>3.0.CO;2-A"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00541299"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200509000-00031"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-12-200212170-00037"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117084"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000231696"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(77)90146-X"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.44.26252"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02436762"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1982.tb02164.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1984.24384225035.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00370817"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/82.4.510"},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1046\/j.1365-2133.1997.d01-1234.x","article-title":"Persistent pruritus after hydroxyethyl starch infusion therapy: a result of long\u2010term storage in cutaneous nerves","volume":"136","author":"Metze D","year":"1977","journal-title":"Br J Dermatol"},{"key":"e_1_2_7_18_2","unstructured":"SteinhoffJ ManskyT ReitzM SchultzK SackK.Pharmakokinetik von hydroxyethylstarke bei patienten unter haemodialyse and haemofiltration.Nieren Hochdruckkr1988:S411\u20104."},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(86)80030-7"},{"key":"e_1_2_7_20_2","first-page":"395","article-title":"Hydroxyethylstarch as replacement in therapeutic plasma exhange","volume":"337","author":"Burgstaler EA","year":"1990","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2001.045003385.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37997454024.x"},{"key":"e_1_2_7_23_2","first-page":"256","article-title":"Effects of hydroxyethyl starch and modified fluid gelatine on phagocytic activity of human neutrophils and monocytes\u2014results of a randomized, prospective clinical study","volume":"27","author":"Jaeger K","year":"2000","journal-title":"Infus Ther Transfus Med"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1997.2170765.x"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1981.21381201811.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200108233450818"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04211-2"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1537-2995.2006.00962.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1537-2995.2006.00962.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T04:45:51Z","timestamp":1695962751000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1537-2995.2006.00962.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,21]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1111\/j.1537-2995.2006.00962.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1537-2995.2006.00962.x","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,21]]}}}