{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:52:29Z","timestamp":1781203949196,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,10,19]],"date-time":"2006-10-19T00:00:00Z","timestamp":1161216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Transfusion of blood products to immunoglobulin\u2003A (IgA)\u2013deficient patients who have developed IgA antibodies can result in serious adverse reactions. To prepare compatible blood components for these patients, blood centers usually maintain a list of IgA\u2010deficient blood donors. An in\u2010house enzyme\u2010linked immunosorbent assay (ELISA) was used to identify new IgA\u2010deficient blood donors.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> An in\u2010house ELISA was used to screen blood samples. IgA\u2010deficient samples, defined as an IgA level below 0.05\u2003mg per dL, were sent to the American Red Cross for confirmatory testing.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Seventy\u2010three confirmed IgA\u2010deficient blood donors were identified among 38,759 screened blood donor samples (frequency, 1:531). IgA antibodies were found in 39 of these 73 blood donors (53%), although only 9 donors had a history of adult IgA exposure (transfusion or pregnancy).<\/jats:p><jats:p><jats:bold>CONCLUSIONS:<\/jats:bold> With a simple in\u2010house ELISA, 73 blood donors were identified as IgA\u2010deficient. From this number, 34 donors, without detectable anti\u2010IgA in their plasma, were added to our IgA\u2010deficient blood donor panel to maximize the management of our inventory of IgA\u2010deficient frozen blood components.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2006.01037.x","type":"journal-article","created":{"date-parts":[[2006,10,19]],"date-time":"2006-10-19T09:42:21Z","timestamp":1161250941000},"page":"2115-2121","source":"Crossref","is-referenced-by-count":16,"title":["Establishment of an immunoglobulin\u2003A\u2013deficient blood donor registry with a simple in\u2010house screening enzyme\u2010linked immunosorbent assay"],"prefix":"10.1111","volume":"46","author":[{"given":"Louis","family":"Thibault","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Beaus\u00e9jour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Jo\u00eblle","family":"De 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