{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:46:08Z","timestamp":1790552768671,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T00:00:00Z","timestamp":1166572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Simian foamy virus (SFV) is an endemic, nonhuman primate (NHP) retrovirus that is transmitted to individuals who work with or hunt NHPs. The cross\u2010species transmission of simian retroviruses is believed to be the etiology of human immunodeficiency virus and human T\u2010lymphotropic virus infections in humans. Although SFV is not pathogenic in the native host, the shared ancestry with other simian retroviruses has brought into question the potential for acquired pathogenicity after cross\u2010species transmission. This study examines whether SFV also shares the traits of transmissibility through the blood supply.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> Within a controlled environment, blood from an SFV\u2010infected monkey was transfused into an SFV\u2010uninfected monkey. Evidence of infection, pathogenic effects, immune correlates, and viral shedding were followed for 6\u2003months after transfusion.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Molecular evidence of SFV infection manifested 8\u2003weeks after transfusion followed by seroconversion 1\u2003week later. Quantitative analysis demonstrated that the highest level of detectable virus was concomitant with seroconversion followed by establishment of a viral \u201cset\u2010point.\u201d Analysis of circulating lymphocytes revealed changes early in infection. Potential routes of transmission of SFV and roles of site\u2010specific immune response are suggested by the late appearance of SFV shedding in the saliva of the transfused animal.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> The blood supply has historically provided a portal through which novel, occult viruses can become disseminated among humans. The demonstration of transmissibility of SFV through whole\u2010blood transfusion, in an NHP model, contributes to the understanding of potential risks associated with blood donation by SFV\u2010infected humans.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2007.01079.x","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T08:20:41Z","timestamp":1166689241000},"page":"162-170","source":"Crossref","is-referenced-by-count":42,"title":["Characterization of blood\u2010borne transmission of simian foamy virus"],"prefix":"10.1111","volume":"47","author":[{"given":"James I.","family":"Brooks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet W.","family":"Merks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roumiana S.","family":"Boneva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Sandstrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,20]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0498-403"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09597-1"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.6.2780-2789.2004"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15787-5"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5453.607"},{"key":"e_1_2_8_7_2","first-page":"299","article-title":"An unusual virus in cultures from a human nasopharyngeal carcinoma","volume":"46","author":"Achong BG","year":"1971","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.6.4821-4824.1997"},{"key":"e_1_2_8_9_2","volume-title":"Preliminary risk assessment on simian foamy virus (SFV) and deferral policy for blood and CTO donation [monograph on the Internet].","author":"Blood Safety Surveillance and Health Care Acquired Infections Division, Centre for Infectious Disease Prevention and Control."},{"key":"e_1_2_8_10_2","volume-title":"Topic II: The potential risk of simian foamy virus transmission by blood transfusion [monograph on the Internet].","author":"Blood Products Advisory Committee.","year":"2004"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00134.x"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1995.1120"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.7883\/yoken1952.34.1"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.1995.tb00182.x"},{"key":"e_1_2_8_15_2","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1099\/0022-1317-75-10-2635","article-title":"Reactivity of primate sera to foamy virus Gag and Bet proteins","volume":"75","author":"Hahn H","year":"1994","journal-title":"J Virol"},{"key":"e_1_2_8_16_2","volume-title":"Protein blotting application guide."},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.1.165-176.2001"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1139\/g00-069"},{"issue":"2","key":"e_1_2_8_19_2","first-page":"1","article-title":"Guidelines for performing single\u2010platform absolute CD4+ T\u2010cell determinations with CD45 gating for persons infected with human immunodeficiency virus. Centers for Disease Control and Prevention","volume":"52","author":"Mandy FF","year":"2003","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/br.39.3.169-185.1975"},{"key":"e_1_2_8_21_2","volume-title":"Canadian Blood Services [homepage on the Internet].","year":"1998"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0703-874"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1996.0371"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(95)02164-7"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.9634"},{"key":"e_1_2_8_26_2","volume-title":"Human infection with simian foamy viruses: preliminary results from a long\u2010term follow\u2010up study [abstract].","author":"Boneva RS","year":"2002"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.10.7305-7311.1997"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-55701-9_1"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16812-8"},{"key":"e_1_2_8_30_2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1155\/2006\/298303","article-title":"Transfusion and risk of infection in Canada: Update 2006","volume":"17","author":"Canadian Paediatric Society Infectious Diseases and Immunization Committee.","year":"2006","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.1.165-176.2001"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-10-733"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-200201000-00007"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16820-7"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1537-2995.2007.01079.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1537-2995.2007.01079.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T06:28:56Z","timestamp":1697264936000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1537-2995.2007.01079.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,20]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1537-2995.2007.01079.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1537-2995.2007.01079.x","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,20]]}}}