{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:20:36Z","timestamp":1777562436244,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T00:00:00Z","timestamp":1174521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Administration of culture\u2010positive hematopoietic progenitor cells (HPCs) causing adverse events has been a hypothesized yet largely unmeasured risk of the clinical practice of HPC transplantation. To enhance patient safety, the FDA has issued regulations prohibiting the use of culture\u2010positive HPCs. Numerous studies have reported the infusion of culture\u2010positive HPCs; however, the low frequency of adverse events prevents accurate determination of this risk.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> Product culture results and clinical outcomes from January 1998 through March 2006 representing 7233 HPC collections for 2118 transplants at a single institution were reviewed.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> A total of 119 units of HPCs (1.6%) intended for 95 patients were culture\u2010positive. Of the 69 patients transplanted with culture\u2010positive HPCs, 5 received products with cultures pending, and 64 received products with the positive culture results known. One of 69 patients had a new positive blood culture 5\u2003days after infusion with the same species as the product. There was not a clinically relevant difference in the rate of infusion\u2010related symptoms reported for patients who received culture\u2010positive products compared to all infusions. The survival of patients who received culture\u2010positive products (n\u2003=\u200369) was not different from all HPC recipients (n\u2003=\u20032046; p\u2003=\u20030.419).<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> No infusion\u2010related risks of culture\u2010positive HPCs to patient safety were identified. Our data suggest that the decision to use culture\u2010positive HPCs must be made in the context of the global risks associated with transplants such as remobilization, replacement product availability, and the nature of the organism.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2007.01165.x","type":"journal-article","created":{"date-parts":[[2007,5,7]],"date-time":"2007-05-07T13:48:37Z","timestamp":1178545717000},"page":"636-643","source":"Crossref","is-referenced-by-count":27,"title":["Sterility testing of hematopoietic progenitor cell products: a single\u2010institution series of culture\u2010positive rates and successful infusion of culture\u2010positive products"],"prefix":"10.1111","volume":"47","author":[{"given":"Douglas\u2003J.","family":"Padley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan\u2003B.","family":"Dietz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis\u2003A.","family":"Gastineau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,22]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(96)90072-9"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(96)90031-6"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1988.28288179011.x"},{"key":"e_1_2_5_5_2","first-page":"241","article-title":"Contamination during in vitro processing of bone marrow for transplantation: clinical significance","volume":"7","author":"Lazarus HM","year":"1991","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.309.6959.958a"},{"key":"e_1_2_5_7_2","first-page":"123","article-title":"Epidemiologic notes and reports reported contamination of heparin sodium with Pseudomonas putida","volume":"35","author":"Cameron S","year":"1986","journal-title":"MMWR"},{"key":"e_1_2_5_8_2","first-page":"22","article-title":"Contamination of processed autologous bone marrows from a contaminated lot of density gradient separation medium","volume":"15","author":"Froggatt JW","year":"1994","journal-title":"Infect Contr Hosp Epidemiol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/374051"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1996.36996420753.x"},{"key":"e_1_2_5_11_2","first-page":"87","article-title":"Microbial contamination of harvested bone marrow and peripheral blood","volume":"15","author":"Prince HP","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.1996.d01-57.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1994.tb05034.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00573.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1996.36996420754.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/14653240310001046"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1996.36196190515.x"},{"key":"e_1_2_5_18_2","unstructured":"Part 1271\u2014human cells tissues and cellular and tissue\u2010based products (69 FR 68681).Fed Regist2004;1271."},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1991.31691306250.x"},{"key":"e_1_2_5_20_2","first-page":"379","article-title":"Incidence of bacterial contamination of bone marrow grafts","volume":"277","author":"Schepers KD","year":"1992","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_5_21_2","first-page":"699","article-title":"Microbial contamination of peripheral blood stem cell collections","volume":"17","author":"Attarian HB","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.04178.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702704"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.1998.7420088.x"},{"key":"e_1_2_5_25_2","first-page":"1232","article-title":"Quality control of bacterial contamination in autologous peripheral blood stem cells for transplantation","volume":"89","author":"Larrea L","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_5_26_2","first-page":"223","article-title":"Peripheral blood progenitor cells have less microbiological contamination than bone marrow [abstract]","volume":"4","author":"Chadwick JR","year":"1995","journal-title":"J Hematother"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.1.1996.5.289"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1086\/514956"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00013.x"},{"key":"e_1_2_5_30_2","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.5858\/2003-127-e19-FOAIOC","article-title":"Favorable outcome after infusion of coagulase\u2010negative staphylococci\u2010contaminated peripheral blood hematopoietic cells for autologous transplantation","volume":"127","author":"Nifong TP","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1080\/14653240310003044"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705421"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705549"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2006.06.011"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1537-2995.2007.01165.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1537-2995.2007.01165.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T07:48:01Z","timestamp":1697269681000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1537-2995.2007.01165.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,22]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1111\/j.1537-2995.2007.01165.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1537-2995.2007.01165.x","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,22]]}}}