{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T12:02:06Z","timestamp":1793707326174,"version":"4.6.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Drug\u2010induced immune hemolytic anemia (DIIHA) is an uncommon finding characterized by a sudden decrease in hemoglobin after treatment with the putative drug. The full range of drugs causing DIIHA and the initial serologic presentation are not fully appreciated. This work identifies additional drugs associated with DIIHA and offers additional insights about diagnosis.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> A 20\u2010year retrospective review of testing in one laboratory was performed. Patient sex, age, medication history, initial direct antiglobulin test (DAT) and indirect antiglobulin test, method of drug\u2010dependent antibody (DDA) detection, and specificity were reviewed.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Seventy\u2010one patients with 73 DDAs to 23 different drugs were identified. The following DDA specificities were identified: cephalosporins (37), penicillin and\/or penicillin derivatives (12), nonsteroidal anti\u2010inflammatory drugs (NSAIDs) (11), quinine and\/or quinidine (7), and others (6). Fifty\u2010two\u2003percent (37) were due to cephalosporins with 27 cefotetan\u2010dependent antibodies detected. Four NSAIDs required urinary metabolite for detection. DAT was strongly positive, at least 2+, in 75\u2003percent (51\/68) of patients with a positive DAT. Initial eluate was negative in 52 patients, weak positive (&lt;2+) in 14 patients, and strong positive (\u22652+) in 2 patients. Serologic results showed characteristics of warm autoimmune hemolytic anemia (AIHA) in 22 or 31\u2003percent of all cases and cold\u2010reactive AIHA in 2 cases.<\/jats:p><jats:p><jats:bold>CONCLUSIONS:<\/jats:bold> It is important to consider DIIHA when a patient serologically presents as either warm\u2010 or cold\u2010type AIHA to avoid erroneous diagnosis. Based on these findings, the strength of the initial DAT is much stronger than previously reported for all types of drug\u2010induced immune hemolysis. This report is also unique in the number of NSAIDs reported. A new classification of categorizing DDA is proposed.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2007.01173.x","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T12:33:34Z","timestamp":1172838814000},"page":"697-702","source":"Crossref","is-referenced-by-count":102,"title":["One center's experience: the serology and drugs associated with drug\u2010induced immune hemolytic anemia\u2014a new paradigm"],"prefix":"10.1111","volume":"47","author":[{"given":"Susan T.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith T.","family":"Fueger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome L.","family":"Gottschall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2005.04.004"},{"key":"e_1_2_7_3_2","volume-title":"AABB technical manual.","year":"2005"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39111239.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1182\/blood.V84.1.176.176","article-title":"Antibodies in sulfonamide\u2010induced immune thrombocytopenia recognize calcium\u2010dependent epitopes on glycoprotein IIb\/IIIa complex","volume":"84","author":"Curtis BR","year":"1994","journal-title":"Blood"},{"key":"e_1_2_7_6_2","first-page":"S77","article-title":"Enhanced detection of drug\u2010dependent antibodies reacting with untreated red blood cells in the presence of drug","volume":"34","author":"Osbourne SE","year":"1994","journal-title":"Transfusion"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.1.407"},{"key":"e_1_2_7_8_2","first-page":"SP239","article-title":"Ceftazidime\u2010dependent antibody reacting with untreated red cells in the presence of drug [abstract]","volume":"41","author":"Fueger JT","year":"2001","journal-title":"Transfusion"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40060663.x"},{"key":"e_1_2_7_10_2","article-title":"Nabumetome metabolite\u2010dependent antibody reacting with untreated red cells in the presence of urinary metabolite [abstract]","volume":"43","author":"Johnson ST","year":"2003","journal-title":"Transfusion"},{"key":"e_1_2_7_11_2","first-page":"S215","article-title":"Ibuprofen\u2010dependent antibody with Rh\u2010specificity reacting with untreated red cells in the presence of drug [abstract]","volume":"36","author":"Johnson ST","year":"1996","journal-title":"Transfusion"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2002.00188.x"},{"key":"e_1_2_7_13_2","first-page":"S290","article-title":"Piperacillin\u2010dependent antibody with relative e specificity reacting with drug treated red cells and untreated red cells in the presence of drug","volume":"34","author":"Johnson ST","year":"1994","journal-title":"Transfusion"},{"key":"e_1_2_7_14_2","first-page":"SP366","article-title":"Levofloxacin\u2010dependent antibody reacting with untreated red cells in the presence of drug [abstract]","volume":"45","author":"Downes KA","year":"2005","journal-title":"Transfusion"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198508223130803"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197208242870803"},{"key":"e_1_2_7_17_2","volume-title":"Immune hemolytic anemia.","author":"Petz LD","year":"2004"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20494"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1537-2995.2007.01173.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1537-2995.2007.01173.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T07:47:11Z","timestamp":1697269631000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1537-2995.2007.01173.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,2]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1111\/j.1537-2995.2007.01173.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1537-2995.2007.01173.x","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,2]]}}}