{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:24:12Z","timestamp":1789025052413,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,4,25]],"date-time":"2007-04-25T00:00:00Z","timestamp":1177459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold>Antibodies with anti\u2010M specificity are detected in 10\u2003percent of pregnant women with a positive antibody screen, but anti\u2010M is only rarely associated with hemolytic anemia in the fetus.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold>This study reports on three pregnancies in one family that all resulted in severe fetal anemia. The first fetus died in utero with hydrops fetalis during the 20th gestational week and the second child was delivered after 28\u2003weeks of gestation with hydrops fetalis and a hemoglobin level of 16\u2003g per L whereas the third affected child was treated with intrauterine red cell (RBC) transfusions before delivery at 28\u2003weeks of gestation.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold>The direct antiglobulin test was negative but anti\u2010M in a low titer was detected through the three pregnancies, and its clinical relevance, which initially was uncertain, was confirmed by pronounced in vivo hemolysis in maternal blood of chromate (<jats:sup>51<\/jats:sup>Cr)\u2010labeled M+ RBCs and normal survival of<jats:sup>51<\/jats:sup>Cr labeled M\u2013 RBCs.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold>It is concluded that anti\u2010M immunization in a few cases may cause severe fetal hemolytic anemia and intrauterine death. It remains to be elucidated why a normally clinically insignificant antibody is this aggressive in a small proportion of cases. Because the condition is treatable, anti\u2010M must be considered as a possible cause of fetal anemia and intrauterine death.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2007.01209.x","type":"journal-article","created":{"date-parts":[[2007,5,6]],"date-time":"2007-05-06T17:43:17Z","timestamp":1178473397000},"page":"911-917","source":"Crossref","is-referenced-by-count":43,"title":["Fetal hemolytic anemia and intrauterine death caused by anti\u2010M immunization"],"prefix":"10.1111","volume":"47","author":[{"given":"Agneta","family":"Wikman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Edner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"Gryfelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baldvin","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan\u2010Inge","family":"Henter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,25]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00476-6"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1959.tb04044.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/43.6.544"},{"key":"e_1_2_8_5_2","first-page":"525","article-title":"A case of haemolytic disease of the newborn caused by anti\u2010M, a serological study of maternal blood","volume":"33","author":"Matsumoto H","year":"1981","journal-title":"Acta Obstet Gynaecol Jpn"},{"key":"e_1_2_8_6_2","first-page":"161","article-title":"Example of a woman with multiple intrauterine deaths due to anti\u2010M who delivered a live child after plasmapheresis","volume":"19","author":"Furukawa K","year":"1993","journal-title":"Exp Clin Immunogenet"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1995.tb03927.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016349609033344"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.20017"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.1997.7220114.x"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-004-0959-3"},{"key":"e_1_2_8_12_2","first-page":"5","volume-title":"Textbook of radiopharmacy.","author":"Danpure HJ","year":"1994"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-198909000-00001"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803193381204"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0958-7578.2005.00562.x"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06073.x"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1054\/blre.1999.0124"},{"key":"e_1_2_8_18_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1423-0410.2000.tb00054.x","article-title":"Expression of red cell surface antigens during erythropoiesis","volume":"78","author":"Daniels G","year":"2000","journal-title":"Vox Sang"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1537-2995.2007.01209.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1537-2995.2007.01209.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T02:22:24Z","timestamp":1736994144000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1537-2995.2007.01209.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,25]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1111\/j.1537-2995.2007.01209.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1537-2995.2007.01209.x","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,25]]}}}