{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T04:45:00Z","timestamp":1697345100427},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,6,7]],"date-time":"2007-06-07T00:00:00Z","timestamp":1181174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Due to the threat of serious or fatal bleedings, fetuses with neonatal alloimmune thrombocytopenia (NAIT) may need intrauterine platelet (PLT) transfusions. To prevent a volume overload or an ABO minor mismatch, standard PLT concentrates need to be washed to increase the PLT concentration and to reduce the plasma content. Hyperconcentrated single\u2010donor PLT concentrates (HCPs) are a therapeutic alternative. The first case of NAIT successfully treated with HCPs collected with the Trima Accel (TA; Gambro BCT) is reported.<\/jats:p><jats:p><jats:bold>CASE REPORT:<\/jats:bold> A 31\u2010year\u2010old woman with a history of NAIT in the preceding pregnancy underwent cordocentesis three times during her third pregnancy (30th, 31st, and 32nd weeks of gestation). NAIT was confirmed by marked fetal thrombocytopenia, a maternal anti\u2010human PLT antigen (HPA)\u20101a\u2013immunoglobulin\u2003G (titer 1:128), and the appropriate HPA genotype of the fetus and the parents. On each cordocentesis procedure, a distinct volume of a HPA\u20101a\u2010negative HCP with a PLT concentration of 3\u2003\u00d7\u200310<jats:sup>6<\/jats:sup> PLTs per \u00b5L was transfused resulting in high corrected count increments after 2\u2003hours. The HCPs were transfused within 10\u2003hours after collection. One day after the last cordocentesis procedure, a cesarean section was performed. The newborn did not show any bleeding signs, and the PLT count remained on normal levels and no further PLT transfusions were needed.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> HCPs collected with TA are a useful alternative to washed standard PLT concentrates without the need for further manipulation of the product after collection. Further in vitro and in vivo studies are needed, however, to make definite recommendations for the shelf life of these HCP.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2007.01288.x","type":"journal-article","created":{"date-parts":[[2007,6,7]],"date-time":"2007-06-07T16:51:44Z","timestamp":1181235104000},"page":"1488-1493","source":"Crossref","is-referenced-by-count":4,"title":["Intrauterine use of hyperconcentrated platelet concentrates collected with Trima Accel in a case of neonatal alloimmune thrombocytopenia"],"prefix":"10.1111","volume":"47","author":[{"given":"Juergen","family":"Ringwald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schroth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Faschingbauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Strobel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin","family":"Strasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf L.","family":"Schild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamme W.","family":"Goecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20282"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91733-9"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.82.3.F173"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1054\/blre.2001.0187"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.04026.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2005.00662.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.05.001"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00533.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.1994.tb00265.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00716.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2004.00536.x"},{"key":"e_1_2_6_13_2","volume-title":"Guidelines for the collection of blood and blood components and the use of blood products (Hemotherapy)","author":"German Medical Association and Paul Ehrlich Institute.","year":"2005"},{"key":"e_1_2_6_14_2","first-page":"376","article-title":"Performance of preparative cellular hemapheresis for the collection of blood cell concentrates. 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