{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:38:58Z","timestamp":1789609138409,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,5,29]],"date-time":"2007-05-29T00:00:00Z","timestamp":1180396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p>\n                    <jats:bold>BACKGROUND:<\/jats:bold>\n                    Delayed severe immune hemolysis due to donor\u2010derived passenger lymphocytes is observed in minor and\/or bidirectional ABO\u2010mismatched transplants, especially after reduced\u2010intensity conditioning (RIC). The incidence is reported in up to 30\u2003percent of patients and can result in multiorgan failure (MOF) and death.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold>\n                    A first group of 32 patients (historical control) underwent RIC followed by allogeneic hematopoietic peripheral blood progenitor cell transplantation at our institution. In 5 of 10 patients with a minor and\/or bidirectional ABO\u2010mismatched graft, severe immune hemolysis was observed, leading to death in 3 of them. Therefore, we initiated a protocol with prophylactic red blood cell (RBC) exchange in minor and\/or bidirectional ABO mismatch of a second group of patients (study group) and investigated the incidence of hemolysis, transplant\u2010related mortality (TRM), and overall survival (OS) and compared these data with the historical control group. Twenty\u2010two of 80 patients in the study group had a minor and\/or bidirectional ABO\u2010mismatched donor.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    In 20 patients, a prophylactic RBC exchange was performed. Three patients showed mild to moderate citrate reactions, and in 1 patient the procedure had to be stopped because of hypotension. Eighteen of 20 patients engrafted uneventfully, 1 patient rejected his graft, and another 1 showed signs of mild hemolysis. In the minor and\/or bidirectional ABO\u2010mismatched setting patients in the study group had a lower risk for TRM at 1\u2003year compared to patients in the historical control group (16% vs. 53%, p\u2003&lt;\u20030.05) and a better 1\u2010year OS (65% vs. 40%, p\u2003&lt;\u20030.05).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION:<\/jats:bold>\n                    RBC exchange is a safe procedure, reducing the incidence of delayed severe immune hemolysis and thus the risk of TRM in minor and\/or bidirectional ABO\u2010mismatched cases.\n                  <\/jats:p>","DOI":"10.1111\/j.1537-2995.2007.01289.x","type":"journal-article","created":{"date-parts":[[2007,5,29]],"date-time":"2007-05-29T22:16:40Z","timestamp":1180477000000},"page":"1494-1502","source":"Crossref","is-referenced-by-count":39,"title":["Prophylactic red blood cell exchange for prevention of severe immune hemolysis in minor ABO\u2010mismatched allogeneic peripheral blood progenitor cell transplantation after reduced\u2010intensity conditioning"],"prefix":"10.1111","volume":"47","author":[{"given":"Nina","family":"Worel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hildegard\u2003T.","family":"Greinix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Supper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerda","family":"Leitner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Mitterbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Rabitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gottfried","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Rosenmayr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"H\u00f6cker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kalhs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,29]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198803000-00005"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700641"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02587.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00209.x"},{"key":"e_1_2_7_6_2","first-page":"50","volume-title":"Manual of clinical laboratory immunology.","author":"Hansen JA","year":"1992"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1995.tb00368.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704741"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.11.3390"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4165"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01879.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402905"},{"key":"e_1_2_7_13_2","first-page":"7","article-title":"Prevention and treatment of cytomegalovirus infection and disease after bone marrow transplantation in the 1990s","volume":"8","author":"Winston DJ","year":"1991","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_7_14_2","first-page":"825","article-title":"1994 Consensus Conference on Acute GVHD Grading","volume":"15","author":"Przepiorka D","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V57.2.267.267"},{"key":"e_1_2_7_16_2","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1182\/blood.V89.9.3113","article-title":"Donor leukocyte infusion for leukemic relapse after allogeneic marrow transplantation: lack of residual donor hematopoiesis predicts aplasia","volume":"89","author":"Keil F","year":"1997","journal-title":"Blood"},{"key":"e_1_2_7_17_2","volume-title":"Technical manual.","author":"Widman FK","year":"1985"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1990.30290162894.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03268.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2217"},{"key":"e_1_2_7_21_2","first-page":"615","article-title":"Lack of effect of donor\u2010recipient ABO mismatching on outcome following allogeneic hematopoietic stem cell transplantation","volume":"38","author":"Klumpp TR","year":"2006","journal-title":"Transfusion"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1998.38398222864.x"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1537-2995.2007.01289.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1537-2995.2007.01289.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T07:43:52Z","timestamp":1697269432000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1537-2995.2007.01289.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,29]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1111\/j.1537-2995.2007.01289.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1537-2995.2007.01289.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1090341.543587","asserted-by":"object"}]},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,29]]}}}