{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:03:05Z","timestamp":1780056185463,"version":"3.54.0"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,5,29]],"date-time":"2007-05-29T00:00:00Z","timestamp":1180396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Fetal\u2010neonatal alloimmune thrombocytopenia (FNAIT) linked to rare or private antigens is not a rare event.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> Such a case discovered during the follow\u2010up of a second child with jaundice with mild thrombocytopenia is reported here. Platelet (PLT) genotyping was performed by polymerase chain reaction (PCR)\u2013sequence\u2010specific primers method and PCR\u2010restriction fragment length polymorphism (RFLP) analysis. Serologic investigation was done with the monoclonal antibody\u2013specific immobilization of PLT antigens technique. Glycoprotein\u2003Ia\u2013specific amplification and sequencing were performed for the polymorphism 807 (exon\u20037).<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> The mother was found to be HPA\u201013aaw, and the father HPA\u201013abw. A maternal alloantibody directed against HPA\u201013bw has been characterized, leading to the diagnosis of neonatal alloimmune thrombocytopenia.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> This report provides further evidence that NAIT associated with low\u2010frequency antigens is not restricted to single families. Therefore, laboratory investigation of a suspected case should be carried out in a specialist laboratory well experienced in optimal testing to propose appropriate management for the index case and subsequent pregnancies.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2007.01291.x","type":"journal-article","created":{"date-parts":[[2007,5,30]],"date-time":"2007-05-30T02:16:40Z","timestamp":1180491400000},"page":"1510-1513","source":"Crossref","is-referenced-by-count":21,"title":["HPA\u201013bw neonatal alloimmune thrombocytopenia and low frequency alloantigens: case report and review of the 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