{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:36:41Z","timestamp":1792676201123,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,8,21]],"date-time":"2007-08-21T00:00:00Z","timestamp":1187654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold>Although the main transmission pathway of parvovirus B19 (B19) is typically via the respiratory route, several transfusion\u2010transmitted infections have been reported. To increase blood safety, all blood donations to our blood donor service have been screened by a B19 minipool real\u2010time nucleic acid testing (NAT) since April 2000. Additional customers have been screened since the summer of 2003.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold>In total, 2.8\u2003million donations from Germany and Austria were screened for B19 by real\u2010time minipool NAT. A subgroup of 50 B19\u2003DNA\u2013positive donors was screened for B19 immunoglobulin\u2003G (IgG) and IgM antibodies and B19 DNA over a 6\u2010month period. Results were compared to those of 100 B19\u2003DNA\u2013negative donors.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold>Data accumulated over the past 6\u2003years indicate a high incidence period from May 2004 to January 2006. In total, the incidence was 12.7 and 261.5 per 100,000 donations with high virus loads equal to or above 10<jats:sup>5<\/jats:sup>and below 10<jats:sup>5<\/jats:sup>IU per mL, respectively. Median virus concentration in the case group was 4.85\u2003\u00d7\u200310<jats:sup>7<\/jats:sup>\u2003IU per mL at Time Point T0 and was reduced to 4\u2003\u00d7\u200310<jats:sup>2<\/jats:sup>\u2003IU per mL at the time of the next donation (3\u2003months later). Neutralizing antibodies (VP2) were detected in all donations if virus load was reduced to less than 10<jats:sup>5<\/jats:sup>\u2003IU per mL.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold>The release of B19\u2003DNA\u2013positive blood products with a concentration of less than 10<jats:sup>5<\/jats:sup>\u2003IU per mL is thought to be safe due to the high level of neutralizing VP2 antibodies and is currently examined in a donor recipient infectivity study. In contrast, blood products with a high B19 DNA concentration (\u226510<jats:sup>5<\/jats:sup>\u2003IU\/mL), some of which did not contain neutralizing antibodies, were discarded to protect at risk individuals.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2007.01443.x","type":"journal-article","created":{"date-parts":[[2007,8,21]],"date-time":"2007-08-21T16:16:19Z","timestamp":1187712979000},"page":"1775-1782","source":"Crossref","is-referenced-by-count":59,"title":["Blood donor screening for parvovirus B19 in Germany and 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