{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:04:09Z","timestamp":1777028649370,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,2,22]],"date-time":"2008-02-22T00:00:00Z","timestamp":1203638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Transfusion\u2010associated circulatory overload (TACO) can be difficult to diagnose and distinguish from transfusion\u2010related acute lung injury (TRALI), but is a relatively common complication that occurs when increases in blood volume overwhelm the cardiovascular system. Brain natriuretic peptide (BNP) has been shown to be a functional marker for TACO. N\u2010terminal pro\u2010brain natriuretic peptide (NT\u2010proBNP) is another marker that could be more helpful than BNP since it has a longer half\u2010life in circulation and is also much more stable in laboratory samples. In this study, whether NT\u2010proBNP is a useful diagnostic marker for TACO was evaluated.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> Forty patients were enrolled into a case\u2010control study (16 patients with TACO and 24 control patients) and had pre\u2010 and posttransfusion NT\u2010proBNP concentrations evaluated from submitted type\u2010and\u2010screen blood samples.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> The sensitivity of elevated posttransfusion NT\u2010proBNP to diagnose TACO was 93.8\u2003percent, the specificity was 83.8\u2003percent, and the accuracy was 87.5\u2003percent. Elevated posttransfusion NT\u2010proBNP is the only independent variable for the diagnosis of TACO based on multivariate logistic regression.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> NT\u2010proBNP is both a sensitive and a specific marker for TACO and can be helpful in confirming transfusion associated fluid overload. This study also demonstrates that many patients who experience TACO may already be in a state of excess volume. Clinicians should be aware that many asymptomatic patients have excess fluid and transfusion may cause these patients to become symptomatic.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2008.01656.x","type":"journal-article","created":{"date-parts":[[2008,2,23]],"date-time":"2008-02-23T07:45:02Z","timestamp":1203752702000},"page":"1143-1150","source":"Crossref","is-referenced-by-count":68,"title":["N\u2010terminal pro\u2010brain natriuretic peptide is a useful diagnostic marker for transfusion\u2010associated circulatory overload"],"prefix":"10.1111","volume":"48","author":[{"given":"Aaron A.R.","family":"Tobian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori J.","family":"Sokoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Tisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul 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