{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:49:48Z","timestamp":1791121788778,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,7,8]],"date-time":"2008-07-08T00:00:00Z","timestamp":1215475200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Five cases of transfusion transmission of hepatitis\u2003E virus (HEV) have been reported so far. The infection routes of the causative donors remain unclear, however. Also, the progress of virus markers in the entire course of HEV infection has not been well documented.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> Nucleic acid testing was performed by real\u2010time reverse transcription\u2013polymerase chain reaction targeting the open reading frame 2 region of HEV. Full\u2010length nucleotide sequences of HEV RNA were detected by direct sequencing.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Lookback study of a HEV\u2010positive donor revealed that the platelets (PLTs) donated from him 2 weeks previously contained HEV RNA and were transfused to a patient. Thirteen relatives including the donor were ascertained to enjoy grilled pork meats together in a barbecue restaurant 23\u2003days before the donation. Thereafter, his father died of fulminant hepatitis E and the other 6 members showed serum markers of HEV infection. In the recipient, HEV was detected in serum on Day\u200322 and reached the peak of 7.2\u2003log copies per mL on Day\u200344 followed by the steep increase of alanine aminotransferase. Immunoglobulin\u2003G anti\u2010HEV emerged on Day\u200367; subsequently, hepatitis was resolved. HEV RNA sequences from the donor and recipient were an identical, Japan\u2010indigenous strain of genotype\u20034. HEV RNA was detectable up to Day\u200397 in serum, Day\u200385 in feces, and Day\u200371 in saliva.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> A transfusion\u2010transmitted hepatitis E case by blood from a donor infected via the zoonotic food\u2010borne route and the progress of HEV markers in the entire course are demonstrated. Further studies are needed to clarify the epidemiology and the transfusion\u2010related risks for HEV even in industrialized countries.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2008.01722.x","type":"journal-article","created":{"date-parts":[[2008,7,8]],"date-time":"2008-07-08T17:00:52Z","timestamp":1215536452000},"page":"1368-1375","source":"Crossref","is-referenced-by-count":250,"title":["A case of transfusion\u2010transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus via zoonotic food\u2010borne 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