{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:19:21Z","timestamp":1792174761684,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,5,23]],"date-time":"2008-05-23T00:00:00Z","timestamp":1211500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> The objective was to investigate the use of autologous red blood cells (RBCs) derived from umbilical cord blood (UCB), as an alternative for allogeneic transfusions in premature infants admitted to a tertiary neonatal center.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> UCB collection was performed at deliveries of less than 32\u2003weeks of gestation and processed into autologous RBC products. Premature infants requiring a RBC transfusion were randomly assigned to an autologous or allogeneic product. The primary endpoint was an at least 50\u2003percent reduction in allogeneic transfusion needs.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Fifty\u2010seven percent of the collections harvested enough volume (\u226515\u2003mL) for processing. After being processed, autologous products (\u226510\u2003mL\/kg) were available for 36\u2003percent of the total study population and for 27\u2003percent of the transfused infants and could cover 58\u2003percent (range, 25%\u2010100%) of the transfusion needs within the 21\u2010day product shelf life. Availability of autologous products depended most on the gestational age. Infants born between 24 and 28\u2003weeks had the lowest availability (17%). All products, however, would be useful in view of their high (87%) transfusion needs. Availability was highest (48%) for the infants born between 28 and 30\u2003weeks. For 42\u2003percent of the infants with transfusion needs in this group, autologous products were available. For the infants born between 30 and 32\u2003weeks, autologous products were available for 36\u2003percent of the infants. Transfusion needs in this group were, however, much lower (19%) compared to the other gestational groups.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> Autologous RBCs derived from UCB could not replace 50\u2003percent of allogeneic transfusions due to the low UCB volumes collected and subsequent low product availability.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2008.01747.x","type":"journal-article","created":{"date-parts":[[2008,5,23]],"date-time":"2008-05-23T18:11:03Z","timestamp":1211566263000},"page":"1634-1643","source":"Crossref","is-referenced-by-count":40,"title":["A clinical study on the feasibility of autologous cord blood transfusion for anemia of prematurity"],"prefix":"10.1111","volume":"48","author":[{"given":"Chantal M.","family":"Khodabux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette S.","family":"Von 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