{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:02:55Z","timestamp":1792569775939,"version":"4.5.0"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,10,14]],"date-time":"2008-10-14T00:00:00Z","timestamp":1223942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Autologous plasma rich in platelets (PRP) is a derived blood product whose application in clinical practice is growing. A systematic review was conducted to evaluate its efficacy and safety.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> A search was performed in electronic databases. Randomized controlled clinical trials (RCTs) in adult patients were included and assessed for methodologic quality. The main outcomes were \u201ctissue regeneration\u201d and \u201csafety.\u201d Relative risks (RRs) and standardized mean differences (SMDs) were calculated to show pooled estimates for these outcomes. When the results heterogeneity was more than 50 percent, a sensitivity analysis was performed.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Twenty RCTs were included (11 of oral and maxillofacial surgery, 7 of chronic skin ulcers, and 2 of surgery wounds). Four RCTs evaluated the depth reduction in gingival recession in chronic periodontitis; the SMD was 0.54 (95% confidence interval [CI], 0.16 to 0.92)\u2003mm, favorable to PRP. Three RCTs evaluated the clinical attachment level in chronic periodontitis; the SMD was 0.33 (95% CI, \u22120.71 to 1.37) mm. Six RCTs assessed the complete skin epithelialization in wound ulcers; the RR was 1.40 (95% CI, 0.85 to 2.31). Only 6 RCTs reported adverse effects without differences between groups.<\/jats:p><jats:p><jats:bold>CONCLUSIONS:<\/jats:bold> PRP improves the gingival recession but not the clinical attachment level in chronic periodontitis. In the complete healing process of chronic skin ulcers, the results are inconclusive. There are little data about PRP safety. There are several methodologic limitations and, consequently, future research should focus on strong and well\u2010designed RCTs that assess the efficacy and safety of PRP.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2008.01945.x","type":"journal-article","created":{"date-parts":[[2008,10,14]],"date-time":"2008-10-14T18:53:11Z","timestamp":1224010391000},"page":"44-56","source":"Crossref","is-referenced-by-count":112,"title":["Efficacy and safety of the use of autologous plasma rich in platelets for tissue regeneration: a systematic review"],"prefix":"10.1111","volume":"49","author":[{"given":"Ma Jos\u00e9","family":"Mart\u00ednez\u2010Zapata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Mart\u00ed\u2010Carvajal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Sol\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignasi","family":"Bolibar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"\u00c1ngel Exp\u00f3sito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,23]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90029-4"},{"key":"e_1_2_7_3_2","first-page":"1","article-title":"Autologous platelets as a source of proteins for healing and tissue regeneration","volume":"92","author":"Anitua E","year":"2004","journal-title":"Thromb Haemost"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30375"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.12.1668"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archfaci.3.4.245"},{"key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1051\/ject\/200537148","article-title":"Autologous platelet gel applications during cardiovascular surgery: effect on wound healing","volume":"37","author":"Englert SJ","year":"2005","journal-title":"J Extra Corpor Technol"},{"key":"e_1_2_7_8_2","first-page":"319","article-title":"The use of platelet derived wound healing formula in human clinical trials","volume":"266","author":"Knighton DR","year":"1988","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/07853890.1993.12088580","article-title":"Growth factors: therapeutic advances in wound healing","volume":"25","author":"Robinson CJ","year":"1993","journal-title":"Ann Med"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1051\/ject\/200537148","article-title":"Autologous platelet gel applications during cardiovascular surgery: effect on wound healing","volume":"37","author":"Crovetti G","year":"2005","journal-title":"J Extra Corpor Technol"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30648-9"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.89B8.18451"},{"key":"e_1_2_7_13_2","first-page":"93","article-title":"Is platelet\u2010rich plasma the perfect enhancement factor? 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