{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:27:24Z","timestamp":1790220444816,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,10,15]],"date-time":"2009-10-15T00:00:00Z","timestamp":1255564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> After HLA\u2010identical hematopoietic stem cell transplantation, minor histocompatibility (mH) antigen alloreactivity plays a dominant role in the development of graft\u2010versus\u2010host disease (GVHD) and graft versus leukemia (GVL).<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> We have analyzed the mH alloreactivity (enzyme\u2010linked immunospot [ELISpot] for interferon\u2010\u03b3[IFN\u2010\u03b3] assay) from 24 donor\/recipient pairs over a period of 2 years of follow\u2010up and correlated such alloreactivity with the development of GVHD or absence of relapse. Circulating specific T cells anti\u2010mH with multimer HLA\u2010peptides were also studied.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> We show by ELISpot IFN\u2010\u03b3 assay that alloreactivity during the first 3 months from donor versus recipient or donor versus mismatched identified mH antigens is associated with acute GVHD and GVL effect. In addition, we demonstrate that the donor\u2010versus\u2010recipient reactivity observed after the third month is highly associated with chronic GVHD and GVL (p\u2003=\u20030.0007). Finally, we show by multimer HLA\u2010peptide assay that mH epitope\u2010specific T cells present after 3 months are statistically related to the GVL effect.<\/jats:p><jats:p><jats:bold>CONCLUSIONS:<\/jats:bold> Our results provide a robust method to monitor mH antigen graft\u2010versus\u2010host reaction and suggest that current identified mH have predictive value on GVHD and GVL.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2009.02440.x","type":"journal-article","created":{"date-parts":[[2009,10,15]],"date-time":"2009-10-15T14:53:56Z","timestamp":1255618436000},"page":"418-428","source":"Crossref","is-referenced-by-count":10,"title":["Immunomonitoring of graft\u2010versus\u2010host minor histocompatibility antigen correlates with graft\u2010versus\u2010host disease and absence of relapse after graft"],"prefix":"10.1111","volume":"50","author":[{"given":"David","family":"Laurin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalil","family":"Hannani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Pernollet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Moine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl","family":"Plumas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Claude","family":"Bensa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Yves","family":"Cahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Garban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27094"},{"key":"e_1_2_8_3_2","first-page":"32","article-title":"Four approaches to estimating number of histocompatibility loci","volume":"2","author":"Bailey DW","year":"1970","journal-title":"Transpl Proc"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/5.9.1003"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199810150-00016"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00185109"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2006.07.012"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1130660"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3501"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030103"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/10563"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000042"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197410000-00001"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1279"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2002.19007.x"},{"key":"e_1_2_8_16_2","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1182\/blood.V80.7.1838.1838","article-title":"Acute graft versus host disease: analysis of risk factors after allogeneic marrow transplantation and prophylaxis with cyclosporine and methotrexate","volume":"80","author":"Nash RA","year":"1992","journal-title":"Blood"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-11-0059"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.12.2459.2459"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2603"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0530192100"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24832"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704583"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7539551"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7667640"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3286"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80330-1"},{"key":"e_1_2_8_27_2","doi-asserted-by":"crossref","first-page":"6360","DOI":"10.4049\/jimmunol.163.12.6360","article-title":"Cutting edge: the HLA\u2010A*0101\u2010restricted HY minor histocompatibility antigen originates from DFFRY and contains a cysteinylated cysteine residue as identified by a novel mass spectrometric technique","volume":"163","author":"Pierce RA","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_8_28_2","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1182\/blood.V95.3.1100.003k42_1100_1105","article-title":"DFFRY codes for a new human male\u2010specific minor transplantation antigen involved in bone marrow graft rejection","volume":"95","author":"Vogt MH","year":"2000","journal-title":"Blood"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03165108"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.8.3027"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.2.195"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.23.9514"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890430119"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1537-2995.2009.02440.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1537-2995.2009.02440.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T19:09:28Z","timestamp":1697310568000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1537-2995.2009.02440.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1111\/j.1537-2995.2009.02440.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1537-2995.2009.02440.x","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}