{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:56:02Z","timestamp":1790420162742,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,10,23]],"date-time":"2009-10-23T00:00:00Z","timestamp":1256256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Although there have been a few reports of immune hemolytic anemia (IHA) thought to be due to cimetidine, none of them provided proof (e.g., serologic detection of anti\u2010cimetidine and\/or repeat of IHA upon drug rechallenge). One report used cimetidine as an example of how temporal associations of drug administration and hemolytic anemia are not proof of a cause\u2010effect relationship.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> A 63\u2010year\u2010old cancer patient developed IHA on two occasions after receiving cimetidine (with and without chemotherapy). Serologic methods included testing cimetidine\u2010treated red blood cells (RBCs) as well as testing untreated RBCs in the presence of cimetidine.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> The patient's direct antiglobulin test was positive (C3 only) and a serum antibody to cimetidine was detected by both testing methods. An eluate from the patient's RBCs was nonreactive. Cimetidine\u2010treated RBCs were optimally prepared at room temperature and needed to be tested on the day of preparation.<\/jats:p><jats:p><jats:bold>CONCLUSIONS:<\/jats:bold> This is the first reported case of IHA due to a cimetidine antibody where a drug\u2010dependent antibody was demonstrated. The patient had IHA after receiving cimetidine on two separate occasions.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2009.02447.x","type":"journal-article","created":{"date-parts":[[2009,10,23]],"date-time":"2009-10-23T12:59:09Z","timestamp":1256302749000},"page":"302-307","source":"Crossref","is-referenced-by-count":9,"title":["Immune hemolytic anemia due to cimetidine: the first example of a cimetidine antibody"],"prefix":"10.1111","volume":"50","author":[{"given":"Patricia A.","family":"Arndt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Garratty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah M.","family":"Brasfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swarajyal L.","family":"Vemuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devi 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