{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T21:06:13Z","timestamp":1792357573485,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T00:00:00Z","timestamp":1258588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Delayed donor red blood cell chimerism (DRCC), pure red blood cell aplasia (PRCA), and autoimmune hemolytic anemia (AIHA) are poorly documented complications after hematopoietic cell transplantation (HCT). The clinical variable \u201cprolonged isolated red blood cell transfusion requirement\u201d (PRTR) was evaluated as a trigger for an extended diagnostic workup.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> PRTR was defined as the need for red blood cell (RBC) transfusions beyond Day 60 after HCT. We analyzed 487 patients transplanted between 2000 and 2006. Median age was 37 years (range, 0\u201070 years). Peripheral blood stem cells (n\u2003=\u2003344), marrow (n\u2003=\u2003138), and cord blood (n\u2003=\u20035) from 278 unrelated and 209 family donors were used.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Univariate analysis identified age (incidence of 18.3% among elderly patients, 10.5% in adults, and 2.0% among children [p\u2003=\u20030.002]), ABO incompatibility (16.4% after major incompatible, 2.9% after minor incompatible, and 9.4% after ABO\u2010compatible transplantations [p\u2003=\u20030.003]), conditioning (15.2% after reduced\u2010intensity regimens vs. 7.3% after myeloablative conditioning; p\u2003=\u20030.006), donor type (13.2% after HLA\u2010matched unrelated, 13.6% after mismatched unrelated, 5.7% after matched related, and 0.0% after mismatched related grafts; p\u2003=\u20030.026), and acute graft\u2010versus\u2010host disease (aGVHD; 7.1% with aGVHD vs. 12.5% without aGVHD; p\u2003=\u20030.046) as predisposing factors. In multivariate analysis minor ABO incompatibility (odds ratio [OR]\u2003=\u20030.2, p\u2003=\u20030.01), younger age (OR\u2003=\u20030.1, p\u2003=\u20030.02), and matched related HCT (OR\u2003=\u20030.4, p\u2003=\u20030.02) remained independent protective factors.<\/jats:p><jats:p><jats:bold>CONCLUSIONS:<\/jats:bold> PRTR could serve as a trigger for a standardized screening for DRCC, PRCA, and AIHA after HCT.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2009.02461.x","type":"journal-article","created":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T17:45:35Z","timestamp":1258652735000},"page":"649-655","source":"Crossref","is-referenced-by-count":18,"title":["TRANSPLANTATION AND CELLULAR ENGINEERING: Prolonged isolated red blood cell transfusion requirement after allogeneic blood stem cell transplantation: identification of patients at risk"],"prefix":"10.1111","volume":"50","author":[{"given":"Daphne","family":"Dahl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Koenecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Gert","family":"Heuft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Dammann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stadler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Buchholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Krauter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Eder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u2010Walter","family":"Sykora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Ganser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,3]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05138.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705641"},{"key":"e_1_2_7_4_2","first-page":"825","article-title":"1994 Consensus Conference on Acute GVHD Grading","volume":"15","author":"Przepiorka D","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.04106.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-007-0304-8"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-8791(98)50004-3"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1977.tb00991.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700677"},{"key":"e_1_2_7_10_2","first-page":"1093","article-title":"Autoimmune hemolytic anemia following T cell\u2010depleted allogeneic bone marrow transplantation","volume":"17","author":"Drobyski WR","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.6.1687"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05364.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197812000-00008"},{"key":"e_1_2_7_14_2","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1182\/blood.V87.2.818.bloodjournal872818","article-title":"The origin of IgG production and homogeneous IgG components after allogeneic bone marrow transplantation","volume":"87","author":"Van Tol MJ","year":"1996","journal-title":"Blood"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198703000-00028"},{"key":"e_1_2_7_16_2","first-page":"445","article-title":"Autoimmune pancytopenia following allogeneic bone marrow transplantation","volume":"6","author":"Klumpp TR","year":"1990","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.1987.tb00381.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198706000-00032"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00918192"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05300.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01289.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1053\/bbmt.2001.v7.pm11669214"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-013318"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02787351"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13356"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1537-2995.2009.02461.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1537-2995.2009.02461.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T01:39:09Z","timestamp":1693705149000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1537-2995.2009.02461.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1111\/j.1537-2995.2009.02461.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1537-2995.2009.02461.x","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}