{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:55:02Z","timestamp":1768424102893,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,10]],"date-time":"2011-01-10T00:00:00Z","timestamp":1294617600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> The authors examined the impact of parenteral iron and recombinant human erythropoietin\u2010\u03b2 (rHuEPO\u2010\u03b2) administered in the bilateral total knee replacement arthroplasty (TKRA), on postoperative anemia and transfusion requirements in iron\u2010deficient patients.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> A total of 108 iron\u2010deficient patients were randomly assigned to two groups: Group C (control) or Group IE (200\u2003mg of iron sucrose intravenously over 1\u2003hr and 3000\u2003IU of rHuEPO\u2010\u03b2 subcutaneously during the operation and during the postoperative period if the hemoglobin [Hb] level was 70\u201080\u2003g\/L). One or 2\u2003units of blood were transfused to patients in both groups according to postoperative Hb level (between 60\u2003and 70\u2003g\/L or betweeen 50\u2003and 60\u2003g\/L, respectively). Perioperative laboratory and clinical outcomes (Hb, iron variables, postoperative bleeding amount, and number of units of RBCs transfused and incidences) were documented.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Although preoperative Hb and the amount of postoperative bleeding were comparable in the two groups, Hb levels at 1, 2, and 3 days and at 2 and 6 weeks postoperation were significantly higher in Group IE. Furthermore, the transfusion rate was significantly lower in Group IE (20.4% vs. 53.7%, p\u2003=\u20030.011) and the mean number of red blood cell units transfused was markedly lower in Group IE (0.2\u2003\u00b1\u20030.5 vs. 0.8\u2003\u00b1\u20030.8, p\u2003=\u20030.005). Postoperative iron, ferritin, and transferrin saturation levels were significantly higher in Group IE.<\/jats:p><jats:p><jats:bold>CONCLUSIONS:<\/jats:bold> Treatment with parenteral iron and low\u2010dose rHuEPO\u2010\u03b2 in bilateral TKRA effectively attenuated anemia and decreased transfusion requirements in iron\u2010deficient patients.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2010.02783.x","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T03:49:01Z","timestamp":1278474541000},"page":"118-124","source":"Crossref","is-referenced-by-count":72,"title":["Effects of intravenous iron combined with low\u2010dose recombinant human erythropoietin on transfusion requirements in iron\u2010deficient patients undergoing bilateral total knee replacement arthroplasty (CME)"],"prefix":"10.1111","volume":"51","author":[{"given":"Hyo\u2010Seok","family":"Na","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon\u2010Young","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Young","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Tae","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong\u2010Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Hwan","family":"Do","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2004.08.008"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0160(00)00047-8"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e318164f114"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00348.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199901000-00002"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2009.00908.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00859.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318184db08"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-006-0173-0"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfi087"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464030-00006"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.suppl_5.14"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc2824"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03021522"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1998.00564.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-11-200012050-00008"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01490506"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.4638"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400601"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002640050284"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(98)90078-X"},{"key":"e_1_2_7_23_2","first-page":"283","article-title":"Risks, 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