{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:21:42Z","timestamp":1790936502422,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T00:00:00Z","timestamp":1297987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> This study was performed to determine the prevalence of antibodies to hepatitis B core antigen (anti\u2010HBc) among Korean blood donors and frequencies of hepatitis B virus (HBV) DNA and antibodies to hepatitis B surface antigen (anti\u2010HBs) in anti\u2010HBc\u2013positive donors.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> A total of 12,461 consenting blood donors were consecutively enrolled from Korean Red Cross Blood Services from April to October 2008. All of the donors were screened for anti\u2010HBc with an electrochemiluminescence immunoassay. Repeat\u2010reactive anti\u2010HBc\u2013positive donors were assayed for anti\u2010HBs and for HBV DNA using a multiplex test (Cobas TaqScreen, Roche Molecular Systems) on individual donation.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Of the 12,461 donors, 1682 (13.5%) were reactive for anti\u2010HBc. Among different age groups, there was a steady increase in the anti\u2010HBc\u2013positive rate, ranging from 2.0% in the age group of less than 20 years to 80.0% in the age group of 60 years and older (p\u2003&lt;\u20030.0001). Of the anti\u2010HBc\u2013positive donors, 1523 (90.5%) were anti\u2010HBs positive. HBV DNA was detected in two donors who were anti\u2010HBc positive and hepatitis B surface antigen negative. The prevalence of occult HBV infection was 0.016%, and the HBV nucleic acid test (NAT) yield was 1 in 838 (0.12%).<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> This study helps to determine the current status of hepatitis B infection and the prevalence of occult HBV infection in the blood donor population in Korea. We estimate that in Korea, up to 161 units per million donated units from blood donors may contain HBV DNA. Although the potential infectivity of these units has been debated upon, the HBV NAT assay could prevent certain transfusion\u2010transmitted HBV infections.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2010.03056.x","type":"journal-article","created":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T15:21:11Z","timestamp":1298042471000},"page":"1840-1846","source":"Crossref","is-referenced-by-count":47,"title":["Prevalence of antibodies to hepatitis B core antigen and occult hepatitis B virus infections in Korean blood donors"],"prefix":"10.1111","volume":"51","author":[{"given":"Dong Hee","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hee","family":"Whang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quehn","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,18]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"202","article-title":"Characteristics of human immunodeficiency virus type 1 reactive blood donors following nucleic acid amplification test screening","volume":"18","author":"Lee JS","year":"2007","journal-title":"Korean J Blood Transfus"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000214633"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2010.02.003"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01701.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0042-9007.2004.00406.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11224"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2006.02.002"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01699.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20354"},{"key":"e_1_2_7_11_2","unstructured":"EMBL\u2010EBI.ClustalW2\u2014Multiple Sequences Alignment. 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