{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:56:13Z","timestamp":1777485373871,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T00:00:00Z","timestamp":1297987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Allogeneic donor natural killer (NK)\u2010cell infusion (NK\u2010DLI) is a promising immunotherapy for patients with hematologic disorders.<\/jats:p><jats:p><jats:bold>CASE REPORT:<\/jats:bold> This report describes the case of a patient who received a single haploidentical NK\u2010DLI for a relapse of acute myeloid leukemia (AML) after haploidentical hematopoietic stem cell transplantation. He underwent a cytoreductive, immunosuppressive regimen before NK\u2010DLI and received high\u2010dose interleukin\u20102 in vivo for 8 weeks afterward.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> No major adverse effect was observed. Prospective phenotypic and functional studies of the NK cells showed major expansion of infused NK cells and, more importantly, of the alloreactive KIR2DL1+KIR2DL2\/DL3\u2013NKG2A\u2013 subset, which reached 117\u2003\u00d7\u200310<jats:sup>6<\/jats:sup> cells\/L on Day +14 after NK\u2010DLI, the greatest expansion of infused alloreactive NK cells reported so far. Infused NK cells conserved their lytic capacities against K562 target cells and primary AML\u2010mismatched blasts.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> We review the literature to clarify these data and to detail the indications for allogeneic NK\u2010DLI, the criteria for determining the most suitable donor, the types of conditioning regimens, and the procedures for selecting and activating NK cells.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2010.03058.x","type":"journal-article","created":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T15:21:28Z","timestamp":1298042488000},"page":"1769-1778","source":"Crossref","is-referenced-by-count":28,"title":["Infusion of allogeneic natural killer cells in a patient with acute myeloid leukemia in relapse after haploidentical hematopoietic stem cell 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