{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:18:05Z","timestamp":1782440285290,"version":"3.54.5"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T00:00:00Z","timestamp":1302739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Ultraviolet B (UVB) light has been used alone on platelet (PLT) transfusion products to prevent alloimmunization or with chemical sensitizers to reduce pathogens. Such processing can damage PLTs and potentiate their storage lesion. Transfusion\u2010related acute lung injury (ALI) has occurred in patients whose underlying condition led to an inflamed endothelium and who were transfused with products that contained either HLA or HNA antibodies or biologic modifiers such as lipids or antigens from stored cells. Clinical trials of UV\u2010treated PLTs in patients with thrombocytopenia generated controversy regarding association of these cells with respiratory distress. We evaluated whether UVB PLTs could mediate ALI in an animal model of ALI.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> We used a two\u2010event animal model where the sensitizing event was lipopolysaccharide (LPS) and the second event was infusion of human PLTs or UVB human PLTs (2.4\u2003J\/cm<jats:sup>2<\/jats:sup>). Infused human PLTs were followed with whole animal imaging, lung histology, confocal microscopy, lung water, and changes in bronchoalveolar lavage fluid (BALF) related to ALI.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> In LPS\u2010treated mice UVB human PLTs accumulated in the lungs and were associated with ALI manifested by increased protein and white blood cells (WBCs) in BALF. Untreated human PLTs did not accumulate in the lungs or increase BALF protein or WBC counts.<\/jats:p><jats:p><jats:bold>CONCLUSIONS:<\/jats:bold> We provide a proof of principle that UVB human PLTs can accumulate in lungs of LPS\u2010primed animals and mediate ALI. PLTs exposed to high doses of UVB could potentially mediate similar effects in patients predisposed with sepsis or other causes of endothelial cell inflammation.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2011.03135.x","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T14:54:43Z","timestamp":1302792883000},"page":"2343-2357","source":"Crossref","is-referenced-by-count":32,"title":["Ultraviolet B light\u2013exposed human platelets mediate acute lung injury in a two\u2010event mouse model of transfusion"],"prefix":"10.1111","volume":"51","author":[{"given":"Monique P.","family":"Gelderman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslav 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