{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:50:09Z","timestamp":1773240609751,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,5,16]],"date-time":"2011-05-16T00:00:00Z","timestamp":1305504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Iron deficiency anemia is an important reason for blood donor deferral. We prospectively determined whether screening donors with hemoglobin (Hb) and iron indices before donation can predict subsequent deferral due to anemia.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> We recruited premenopausal, eligible (nonanemic) female donors. Hb, ferritin, soluble transferrin receptor (sTfR), and hepcidin were measured, and the sTfR\/(log)ferritin (sTfR\u2010F) index was calculated. After 6 months, the donor database was reviewed and whether donors had returned and undergone successful donation was recorded.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Of donors, 59 of 261(22.6%) were iron depleted (ferritin\u2003&lt;\u200315\u2003ng\/mL). Iron\u2010depleted donors had donated more often in the previous year, were younger, and had lower Hb. After a minimum of 6 months, 145 eligible donors had returned; of these 10 (6.9%) were deferred for anemia. Donors who developed anemia had significantly lower Hb, ferritin, and hepcidin and higher sTfR and sTfR\u2010F at baseline. The area under the receiver operating characteristic curve for Hb as a predictor of deferral was 0.86, and for ferritin was 0.88. Hb\u2003of less than 130\u2003g\/L and ferritin\u2003of less than 10\u2003ng\/mL combined had sensitivity 80% and specificity 96% in predicting deferral.<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold> Screening with Hb and iron indices enables prediction of donors at risk of subsequent anemia and who would most benefit from prevention strategies.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2011.03173.x","type":"journal-article","created":{"date-parts":[[2011,5,16]],"date-time":"2011-05-16T16:56:26Z","timestamp":1305564986000},"page":"2709-2713","source":"Crossref","is-referenced-by-count":26,"title":["Hemoglobin and iron indices in nonanemic premenopausal blood donors predict future deferral from whole blood donation"],"prefix":"10.1111","volume":"51","author":[{"given":"Sant\u2010Rayn","family":"Pasricha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe K.","family":"McQuilten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica M.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,5,16]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.3.778"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.26692D"},{"issue":"3","key":"e_1_2_8_4_2","first-page":"CD004736","article-title":"Effects of routine oral iron supplementation with or without folic acid for women during pregnancy (Cochrane Review)","author":"Pena\u2010Rosas JP","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02649.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02881.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02392.x"},{"key":"e_1_2_8_8_2","unstructured":"ARCBS.Guidelines for the selection of blood donors: Australian Red Cross Blood Service.2010."},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02865.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.5694\/j.1326-5377.2010.tb04038.x","article-title":"Diagnosis and management of iron deficiency anaemia: a clinical update","volume":"193","author":"Pasricha SR","year":"2011","journal-title":"Med J Aust"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-139915"},{"key":"e_1_2_8_12_2","volume-title":"Iron deficiency anaemia: assessment, prevention, and control. A guide for programme managers","author":"WHO\/UNICEF\/UNU","year":"2001"},{"key":"e_1_2_8_13_2","volume-title":"Iron deficiency, erythropoietic status in anemia, rHuEPO therapy: new diagnostic approaches\u2014the \u201cThomas\u2010plot.\u201d","author":"Thomas L","year":"2005"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/66.2.334"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2001.1.422"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00969.x"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1537-2995.2011.03173.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1537-2995.2011.03173.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T01:05:40Z","timestamp":1697245540000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1537-2995.2011.03173.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,16]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1111\/j.1537-2995.2011.03173.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1537-2995.2011.03173.x","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,16]]}}}