{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:44:36Z","timestamp":1761101076571},"reference-count":73,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,5,16]],"date-time":"2011-05-16T00:00:00Z","timestamp":1305504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> The purpose of this study was to perform a detailed analysis of the charges associated with chemomobilization and remobilization of autologous hematopoietic stem cells (HSCs) and to quantify medical costs and resource utilization associated with these procedures.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> Patients with lymphoma underwent chemomobilization with ifosfamide and etoposide with or without rituximab (IE\u2003\u00b1\u2003R). Patients with multiple myeloma (MM) received a modified hyperfractionated cyclophosphamide, vincristine, doxorubicin, dexamethasone (hyper\u2010CVAD) regimen after failing to mobilize with growth factors only.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> Between January 2004 and October 2006, 98 patients with lymphoma underwent HSC mobilization with IE\u2003\u00b1\u2003R. Mobilization with IE\u2003\u00b1\u2003R was effective, with 90.8% of patients collecting at least 2\u2003\u00d7\u200310<jats:sup>6<\/jats:sup> CD34+ cells\/kg. The total charges for treatment were $27,996 and $37,667 for patients mobilized with IE and IE\u2003+\u2003R, respectively. Hospital readmission for complications occurred in 26.5% of patients, resulting in additional charges of $10,356. The preapheresis procedure charge was estimated to be $2522, the charge for a 2\u2010day apheresis session was $5160, and the postapheresis phase resulted in charges of $8040. Our analysis determined that reducing apheresis by 1 day has the potential to save $6600. We also performed a retrospective analysis of 16 patients with MM remobilized with a modified hyper\u2010CVAD regimen. Remobilization was successful, with 87.5% of patients. Our analysis determined that mobilization, preapheresis, apheresis, and postapheresis phase charges were $24,968, $2522, $6158, and $12,060, respectively.<\/jats:p><jats:p><jats:bold>CONCLUSIONS:<\/jats:bold> Optimization of HSC mobilization regimens to reduce failure rates would not only benefit patients but also reduce the overall medical costs.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2011.03176.x","type":"journal-article","created":{"date-parts":[[2011,5,16]],"date-time":"2011-05-16T16:58:29Z","timestamp":1305565109000},"page":"1300-1313","source":"Crossref","is-referenced-by-count":17,"title":["Assessing the charges associated with hematopoietic stem cell mobilization and remobilization in patients with lymphoma and multiple myeloma undergoing autologous hematopoietic peripheral blood stem cell transplantation"],"prefix":"10.1111","volume":"51","author":[{"given":"Chitra","family":"Hosing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent","family":"Walters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richmond","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muzaffar","family":"Qazilbash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issa","family":"Khouri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Balzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"McMannis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Champlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Giralt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uday","family":"Popat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,5,16]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"435","volume-title":"The EBMT handbook: haematopoietic stem cell transplantation","author":"Johnston A","year":"2008"},{"key":"e_1_2_7_3_2","first-page":"96","article-title":"Management of nodal diffuse large B\u2010cell lymphomas: practice guidelines from the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation","volume":"91","author":"Barosi G","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2010.0021"},{"key":"e_1_2_7_5_2","unstructured":"American Society for Blood and Marrow Transplantation.The role of cytotoxic therapy with hematopoietic stem cell transplantation in the treatment of diffuse large B cell lymphoma: update of the 2001 evidence\u2010based review. 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