{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:57:13Z","timestamp":1790060233172,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,8,9]],"date-time":"2011-08-09T00:00:00Z","timestamp":1312848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Sickle cell disease (SCD) patients have dissimilar red blood cell (RBC) phenotypes compared to the primarily Caucasian blood donor base due, in part, to underlying complex Rh and silenced Duffy expression. Gene array\u2013based technology offers high\u2010throughput antigen typing of blood donors and can identify patients with altered genotypes. The purpose of the study was to ascertain if RBC components drawn from predominantly Caucasian donors could provide highly antigen\u2010matched products for molecularly typed SCD patients.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold> SCD patients were genotyped by a molecular array (HEA Beadchip, BioArray Solutions). The extended antigen phenotype (C, c, E, e, K, k, Jk<jats:sup>a<\/jats:sup>, Jk<jats:sup>b<\/jats:sup>, Fy<jats:sup>a<\/jats:sup>, Fy<jats:sup>b<\/jats:sup>, S, s) was used to query the inventory using different matching algorithms; the resulting number of products was recorded.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold> A mean of 96.2 RBC products was available for each patient at basic\u2010level, 34 at mid\u2010level, and 16.3 at high\u2010level stringency. The number of negative antigens correlated negatively with the number of available products. The Duffy silencing mutation in the promoter region (67T&gt;C) (<jats:italic>GATA<\/jats:italic>) was found in 96.5% of patients. Allowing Fy(b+) products for patients with <jats:italic>GATA<\/jats:italic> increased the number of available products by up to 180%, although it does not ensure prevention of Duffy antibodies in all patients.<\/jats:p><jats:p><jats:bold>CONCLUSIONS:<\/jats:bold> This feasibility study provides evidence that centers with primarily Caucasian donors may be able to provide highly antigen\u2010matched products. Knowledge of the <jats:italic>GATA<\/jats:italic> status expands the inventory of antigen\u2010matched products. Further work is needed to determine the most clinically appropriate match level for SCD patients.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2011.03288.x","type":"journal-article","created":{"date-parts":[[2011,8,9]],"date-time":"2011-08-09T14:04:34Z","timestamp":1312898674000},"page":"381-388","source":"Crossref","is-referenced-by-count":51,"title":["Molecular blood typing augments serologic testing and allows for enhanced matching of red blood cells for transfusion in patients with sickle cell disease"],"prefix":"10.1111","volume":"52","author":[{"given":"Katie","family":"Wilkinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Gaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Askale","family":"Haile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalind","family":"Armour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayle","family":"Teramura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Delaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,9]]},"reference":[{"key":"e_1_2_8_2_2","volume-title":"Genes and disease","author":"National Center for Biotechnology Information (NCBI, US)","year":"1998"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17192-4"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807023390102"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41091086.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01449.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2002.00396.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2006.1.48"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00007.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22647"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01178.x"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470987018"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2009.1.178"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.5858\/2005-129-190-PMODRB"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.00369.x"},{"key":"e_1_2_8_16_2","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1182\/blood.V85.10.2937.bloodjournal85102937","article-title":"Transcript analysis of D category phenotypes predicts hybrid rh D\u2010CE\u2010D proteins associated with alteration of D epitopes","volume":"85","author":"Rouillac C","year":"1995","journal-title":"Blood"},{"key":"e_1_2_8_17_2","unstructured":"International Society for Blood Transfusion.Draft terminology for blood group alleles.2010[cited 2010 Oct 22]. 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