{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:57:41Z","timestamp":1760608661449,"version":"3.38.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,9,26]],"date-time":"2011-09-26T00:00:00Z","timestamp":1316995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold>The lymphocyte surface glycoprotein CD26 anchors adenosine deaminase to the lymphocyte surface and possesses dipeptidyl peptidase IV activity. A distinct subset of CD26++ lymphocytes in autologous hematopoietic progenitor cell transplants (HPCTs) was investigated with regard to clinical outcome after autologous HPCT. The phenotype of these cells was characterized in more detail.<\/jats:p><jats:p><jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold>Forty\u2010two eligible patients (multiple myeloma, n\u2003=\u200331; Hodgkin's disease, n\u2003=\u20033; non\u2010Hodgkin's lymphoma, n\u2003=\u20036; peripheral neuroectodermal tumor, n\u2003=\u20031; acute myeloid leukemia, n\u2003=\u20031) were included in a retrospective analysis. Distinct cellular subsets, including CD26+\/\u2212 and CD26++ subpopulations, were analyzed for correlations with kinetics of engraftment, progression\u2010free survival, and overall survival.<\/jats:p><jats:p><jats:bold>RESULTS:<\/jats:bold>The numbers of CD26++ T lymphocytes in the autograft correlated inversely with progression\u2010free survival (p\u2003=\u20030.013). CD26++ T lymphocytes transfused per kg of body weight were predictive for the occurrence of disease progression or relapse (p\u2003=\u20030.006). Importantly, the numbers of CD26++ cells showed a highly variable degree of enrichment in the autograft, but no significant variations in the peripheral blood before apheresis. The characterization of CD26++ cells revealed that CD26++\/CD8+ cells form a homogeneous population with a distinct T memory cell phenotype (CD45RO+, CD161++, interleukin\u201018R\u03b1++, CCR7\u2212).<\/jats:p><jats:p><jats:bold>CONCLUSION:<\/jats:bold>CD26++ lymphocytes define a discrete phenotype of T memory cells with known chemoresistance and T\u2010cell\u2010repopulating capacity. Their enrichment during apheresis and corresponding depletion from the circulation are associated with an adverse outcome in autologous HPCT.<\/jats:p>","DOI":"10.1111\/j.1537-2995.2011.03351.x","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T00:41:35Z","timestamp":1317170495000},"page":"765-776","source":"Crossref","is-referenced-by-count":3,"title":["Apheresis\u2010related enrichment of CD26++ T lymphocytes: phenotypic characterization and correlation with unfavorable outcome in autologous hematopoietic progenitor cell transplantation"],"prefix":"10.1111","volume":"52","author":[{"given":"Martin","family":"Hildebrandt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothea","family":"Dijkstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hella","family":"Gollasch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Daemen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Stevanovic\u2010Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolf\u2010Dieter","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,26]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512073332305"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607113350204"},{"key":"e_1_2_8_4_2","first-page":"442","article-title":"Single 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