{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:01:58Z","timestamp":1790146918843,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T00:00:00Z","timestamp":1318464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>\n                    <jats:bold>BACKGROUND:<\/jats:bold>\n                    A combination of antenatal and postnatal RhD prophylaxis is more effective in reducing D immunization in pregnancy than postnatal RhD prophylaxis alone. Based on the result from antenatal screening for the fetal\n                    <jats:italic>RHD<\/jats:italic>\n                    gene, antenatal RhD prophylaxis in Denmark is given only to those D\u2212 women who carry a D+ fetus. We present an evaluation of the first national clinical application of antenatal\n                    <jats:italic>RHD<\/jats:italic>\n                    screening.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>STUDY DESIGN AND METHODS:<\/jats:bold>\n                    In each of the five Danish health care regions, blood samples were drawn from D\u2212 women in Gestational Week 25. DNA was extracted from the maternal plasma and analyzed for the presence of the\n                    <jats:italic>RHD<\/jats:italic>\n                    gene by real\u2010time polymerase chain reaction targeting two\n                    <jats:italic>RHD<\/jats:italic>\n                    exons. Prediction of the fetal RhD type was compared with serologic typing of the newborn in 2312 pregnancies, which represented the first 6 months of routine analysis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    For the detection of fetal\n                    <jats:italic>RHD<\/jats:italic>\n                    , the sensitivity was 99.9%. The accuracy was 96.5%. The recommendation for unnecessary antenatal RhD prophylaxis for women carrying a D\u2212 fetus was correctly avoided in 862 cases (37.3%), while 39 women (1.7%) were recommended for antenatal RhD prophylaxis unnecessarily. Two\n                    <jats:italic>RHD<\/jats:italic>\n                    + fetuses (0.087%) were not detected, and antenatal RhIG was not given.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION:<\/jats:bold>\n                    These data represent the first demonstration of the reliability of routine antenatal fetal\n                    <jats:italic>RHD<\/jats:italic>\n                    screening in D\u2212, pregnant women to ascertain the requirement for antenatal RhD prophylaxis. Our findings should encourage the implementation of such screening programs worldwide, to reduce the unnecessary use of RhIG.\n                  <\/jats:p>","DOI":"10.1111\/j.1537-2995.2011.03362.x","type":"journal-article","created":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T23:21:40Z","timestamp":1318548100000},"page":"752-758","source":"Crossref","is-referenced-by-count":142,"title":["Report of the first nationally implemented clinical routine screening for fetal\n                    <i>RHD<\/i>\n                    in D\u2212 pregnant women to ascertain the requirement for antenatal RhD prophylaxis"],"prefix":"10.1111","volume":"52","author":[{"given":"Frederik 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